Abstract

The Headquarters Office of the Gynecologic OncologyGroup (GOG) under the direction of the Chairman, Dr. George Lewis, in submission of the renewal grant has stated the objectives, goals, and progress of the group. As an active member of the GOG, the Gynecologic Oncology Division of the Department of Obstetrics and Gynecology of the Duke University Medical Center endoreses those objectives and goals. In essence, the basic objectives of the proposed work is to improve the health care for women with or at risk for gynecologic cancer. Objectives of the proposed work include the conduct of clinical trials in gynecologic oncology, multi-discipline coordination and progressive development of protocol studies from pilot and/or Phase II level to Phase III level. Results of protocol research will be used in the development of new generation studies on a continual basis. Studies will be coordinated by an operation and a statistical office to provide data handling, quality control, analysis and dissemination of results. In addition, the Group will serve as a research base for the CCOP and Cancer Control Programs. Coordination of protocol studies will be developed with other groups such at RTOG and regional cooperative groups as they express interest.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA012534-15
Application #
3556158
Study Section
Cancer Clinical Investigation Review Committee (CCI)
Project Start
1978-06-01
Project End
1988-04-30
Budget Start
1985-05-01
Budget End
1986-04-30
Support Year
15
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Duke University
Department
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Sutton, Gregory; Axelrod, Janice H; Bundy, Brian N et al. (2006) Adjuvant whole abdominal irradiation in clinical stages I and II papillary serous or clear cell carcinoma of the endometrium: a phase II study of the Gynecologic Oncology Group. Gynecol Oncol 100:349-54
Tate Thigpen, J; Blessing, John A; DeGeest, Koen et al. (2004) Cisplatin as initial chemotherapy in ovarian carcinosarcomas: a Gynecologic Oncology Group study. Gynecol Oncol 93:336-9
Thigpen, J Tate; Blessing, John A; Olt, George et al. (2003) Cisplatin as second-line therapy in ovarian carcinoma treated initially with single-agent paclitaxel: a Gynecologic Oncology Group study. Gynecol Oncol 90:581-6
Spirtos, Nick M; Westby, Cynthia M; Averette, Hervy E et al. (2002) Blood transfusion and the risk of recurrence in squamous cell carcinoma of the cervix: a gynecologic oncology group study. Am J Clin Oncol 25:398-403
Zaino, R; Whitney, C; Brady, M F et al. (2001) Simultaneously detected endometrial and ovarian carcinomas--a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study. Gynecol Oncol 83:355-62
Whitney, C W; Stehman, F B (2000) The abandoned radical hysterectomy: a Gynecologic Oncology Group Study. Gynecol Oncol 79:350-6
Hernandez, E; Donohue, K A; Anderson, L L et al. (2000) The significance of thrombocytosis in patients with locally advanced cervical carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 78:137-42
Creasman, W T; DeGeest, K; DiSaia, P J et al. (1999) Significance of true surgical pathologic staging: a Gynecologic Oncology Group Study. Am J Obstet Gynecol 181:31-4
Whitney, C W; Sause, W; Bundy, B N et al. (1999) Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study. J Clin Oncol 17:1339-48
Creasman, W T; Zaino, R J; Major, F J et al. (1998) Early invasive carcinoma of the cervix (3 to 5 mm invasion): risk factors and prognosis. A Gynecologic Oncology Group study. Am J Obstet Gynecol 178:62-5

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