The Cedar Rapids Oncology Project (CROP) aims to build on the more than 20 year history of providing access to NCI sponsored cancer treatment and prevention clinical trials to the people in Eastern Iowa and Western Illinois. Cancer remains one of the leading causes of death in the United States. The statistics from the American Cancer Society show a very slight trend in lower incidence and mortality this year. Controlled scientific clinical trials are necessary to sustain and improve this trend. CROP epitomizes the CCOP program with its location in a community oncology practice and its ability to provide the latest cancer treatment to patients without the need to travel to a major cancer center. This allows patients to receive the most current treatments close to home and community physicians to use and stay current with the latest cancer treatments. CROP was funded as a CCOP in 1990 and serves an eleven county area of Eastern Iowa and Western Illinois with a population base of approximately 500,000. The CCOP is a consortium that includes a community based oncology practice and two community hospitals in Cedar Rapids, and Trinity Medical Center in Moline IL, where three oncology practices are located. About 60% of the cancer care in this region is provided by the CCOP components. The CCOP's primary research base membership is the NCCTG and it is an affiliate member of ECOG. The treating locations also access clinical trials through the CTSU. The CCOP has been a site for all the national cancer prevention studies and continues to follow STAR and SELECT participants. The CCOP has an established structure for governance, financial management and IRB oversight. Eighteen years of CCOP experience and over 20 years of clinical trial experience has produced a cohesive and knowledgeable team of investigators and a stable and highly experienced research staff who consistently submit high quality data on time. Over the past five years, the CCOP has met its accrual targets with 261 treatment credits and 261 cancer control credits. The CCOP's successful performance is documented by the accompanying research base evaluations and detailed research plan.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-SRRB-Y (J1))
Program Officer
Kelaghan, Joseph
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Cedar Rapids Oncology Project
Cedar Rapids
United States
Zip Code
Leal, Alexis D; Qin, Rui; Atherton, Pamela J et al. (2014) North Central Cancer Treatment Group/Alliance trial N08CA-the use of glutathione for prevention of paclitaxel/carboplatin-induced peripheral neuropathy: a phase 3 randomized, double-blind, placebo-controlled study. Cancer 120:1890-7
Province, M A; Goetz, M P; Brauch, H et al. (2014) CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations. Clin Pharmacol Ther 95:216-27
Van Loon, Katherine; Espinoza, Anne M; Fogelman, David R et al. (2014) Should combination chemotherapy serve as the backbone in clinical trials of advanced pancreatic cancer? A pooled analysis of phase II trials of gemcitabine-containing doublets plus bevacizumab. Pancreas 43:343-9
Galanis, Evanthia; Anderson, S Keith; Lafky, Jackie M et al. (2013) Phase II study of bevacizumab in combination with sorafenib in recurrent glioblastoma (N0776): a north central cancer treatment group trial. Clin Cancer Res 19:4816-23
Kottschade, Lisa A; Suman, Vera J; Perez, Domingo G et al. (2013) A randomized phase 2 study of temozolomide and bevacizumab or nab-paclitaxel, carboplatin, and bevacizumab in patients with unresectable stage IV melanoma : a North Central Cancer Treatment Group study, N0775. Cancer 119:586-92
Uhm, Joon H; Ballman, Karla V; Wu, Wenting et al. (2011) Phase II evaluation of gefitinib in patients with newly diagnosed Grade 4 astrocytoma: Mayo/North Central Cancer Treatment Group Study N0074. Int J Radiat Oncol Biol Phys 80:347-53
Loprinzi, Charles L; Reeves, Brandi N; Dakhil, Shaker R et al. (2011) Natural history of paclitaxel-associated acute pain syndrome: prospective cohort study NCCTG N08C1. J Clin Oncol 29:1472-8
Laack, Nadia N; O'Neill, Brian Patrick; Ballman, Karla V et al. (2011) CHOD/BVAM chemotherapy and whole-brain radiotherapy for newly diagnosed primary central nervous system lymphoma. Int J Radiat Oncol Biol Phys 81:476-82
Barton, Debra L; Atherton, Pamela J; Bauer, Brent A et al. (2011) The use of Valeriana officinalis (Valerian) in improving sleep in patients who are undergoing treatment for cancer: a phase III randomized, placebo-controlled, double-blind study (NCCTG Trial, N01C5). J Support Oncol 9:24-31
Loprinzi, Charles L; Balcueva, Ernie P; Liu, Heshan et al. (2011) A phase III randomized, double-blind, placebo-controlled study of pilocarpine for vaginal dryness: North Central Cancer Treatment group study N04CA. J Support Oncol 9:105-12

Showing the most recent 10 out of 113 publications