Montana Cancer Consortium CCOP (MCC) has since 1996 provided access to NCI-sponsored clinical trials for the oncology community of Montana and Wyoming. MCC serves over 1 million people in a rural area covering nearly 200,000 square miles. Montana health care quality ranks among the highest in the country, but access to care ranks low due to the vastness of the region and concentration of the medical community in a few widespread cities. The CCOP membership includes 12 affiliate performance sites and 39 physician members. As the physicians work to access the population through outlying clinics hundreds of miles from home, MCC provides access to state-of-the-art cancer treatment, prevention, and control via cutting-edge research of NCI-sponsored trials. This uniquely rural population includes seven Montana Native American reservations that do not have convenient access to large university-based treatment facilities. Without nationally-recognized clinical trial, patients would not have access to a high level of cancer care. MCC intends to extend access by expanding the physician roster to include other disciplines such as surgery and pediatric oncology. MCC is currently affiliated with four adult research bases, SWOG, NSABP, NCCTG, and RTOG as well as CTSU. MCC is actively pursuing affiliation with COG with the addition of pediatric oncology services in two of the affiliate sites. COG membership will expand the CCOP membership and patient base and increase the number of patients accrued annually. MCC accrual has declined over the last grant cycle;however revised membership requirements and renewed interest of participating members is expected to positively impact accrual in the future. MCC is dedicated to maintaining a quality program. Centralized research coordination and an internal quality assurance program ensures quality data, patient safety, and clinical trial compliance. Human subject protection is achieved through local centralized IRB review and annual membership requirements. Drug accountability is met through use of a centralized pharmacy and supervised satellites. The MCC goal is to maintain and enhance this level of quality through education and increased communication and to increase accrual over the next grant cycle.

Public Health Relevance

The uniquely rural population of Montana and Wyoming lacks convenient access to large university-based treatment facilities. Without nationally-recognized clinical trials patients would not have access to a high level of cancer care. Montana Cancer Consortium provides access to state-of-the-art cancer treatment, prevention, and control through cutting edge research of NCI-sponsored clinical trials.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Cooperative Clinical Research--Cooperative Agreements (U10)
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Special Emphasis Panel (ZCA1-SRLB-B (J1))
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St Germain, Diane
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Montana Cancer Consortium
United States
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Yao, S; Sucheston, L E; Zhao, H et al. (2014) Germline genetic variants in ABCB1, ABCC1 and ALDH1A1, and risk of hematological and gastrointestinal toxicities in a SWOG Phase III trial S0221 for breast cancer. Pharmacogenomics J 14:241-7
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Erba, Harry P; Othus, Megan; Walter, Roland B et al. (2014) Four different regimens of farnesyltransferase inhibitor tipifarnib in older, untreated acute myeloid leukemia patients: North American Intergroup Phase II study SWOG S0432. Leuk Res 38:329-33
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Deininger, Michael W; Kopecky, Kenneth J; Radich, Jerald P et al. (2014) Imatinib 800 mg daily induces deeper molecular responses than imatinib 400 mg daily: results of SWOG S0325, an intergroup randomized PHASE II trial in newly diagnosed chronic phase chronic myeloid leukaemia. Br J Haematol 164:223-32
Allen, Jeffrey W; Moon, James; Redman, Mary et al. (2014) Southwest Oncology Group S0802: a randomized, phase II trial of weekly topotecan with and without ziv-aflibercept in patients with platinum-treated small-cell lung cancer. J Clin Oncol 32:2463-70
Philip, Philip A; Goldman, Bryan; Ramanathan, Ramesh K et al. (2014) Dual blockade of epidermal growth factor receptor and insulin-like growth factor receptor-1 signaling in metastatic pancreatic cancer: phase Ib and randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib (SWO Cancer 120:2980-5
Coleman, Robert L; Moon, James; Sood, Anil K et al. (2014) Randomised phase II study of docetaxel plus vandetanib versus docetaxel followed by vandetanib in patients with persistent or recurrent epithelial ovarian, fallopian tube or primary peritoneal carcinoma: SWOG S0904. Eur J Cancer 50:1638-48
Goldkorn, Amir; Ely, Benjamin; Quinn, David I et al. (2014) Circulating tumor cell counts are prognostic of overall survival in SWOG S0421: a phase III trial of docetaxel with or without atrasentan for metastatic castration-resistant prostate cancer. J Clin Oncol 32:1136-42

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