The Winship Cancer Institute (Winship) at Emory University is a university-based cancer center that supports, facilitates and coordinates all cancer research, cancer care and cancer-related education within Emory University, Winship is the first and only NCI-designated cancer center in the state of Georgia, the 8th most populous state in the union. As such, Winship is a transformative leader in integrating cancer research and care aimed at reducing the burden of cancer for the citizens of Georgia and the Southeastern region. Winship has a strong commitment to the inclusion of minorities in clinical research, with approximately 30% of participants in its clinical research trials in 2012 identified as African- American. Winship investigators are conducting innovative therapeutic and non-therapeutic trials across the oncology spectrum. The accomplishments presented in this application are highly relevant to Winship's participation in NCI National Clinical Trials Network (NCTN) and to the growing collaborative research opportunities available between the NCI NCTN network groups and Winship. Winship has participated in clinical trials conducted by all ten of the currently existing NCI-supported cancer cooperative groups. Over the past 5 years Winship investigators have accrued over 500 adult patients to cooperative group clinical trials at Emory University and its affiliates. We have seen a steady increase in accruals over this time period demonstrated by a greater than 50% increase in accruals between 2007 and 2012. This demonstrates the commitment of Winship to continue to provide benefit to our patients through innovative clinical research. Winship investigators have also led the accrual of over 488 young adult and adolescent patients to COG trials since 2007. During the same time period, Winship investigators have designed and/or chaired over 20 trials through the adult cooperative groups. The goal of this application is to sustain and increase the level of engagement between Winship and the NCTN and its network groups in terms of scientific and administrative leadership as well as accrual to NCTN trials.
Winship investigators have played a major role in the national cooperative groups by providing leadership to various disease committees and groups. They have also been consistent contributors to patient accrual as evidenced by a steady Increase in number of patients accrued to cooperative group studies at Winship. Combined with our scientific strengths, patient resources, especially accrual of minority patients, Winship is wel positioned to make robust contributions to the NCTN.
|Meropol, Neal J; Feng, Yang; Grem, Jean L et al. (2018) Phase 2 study of treatment selection based on tumor thymidylate synthase expression in previously untreated patients with metastatic colorectal cancer: A trial of the ECOG-ACRIN Cancer Research Group (E4203). Cancer 124:688-697|
|Sparano, Joseph A; Gray, Robert J; Makower, Della F et al. (2018) Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer. N Engl J Med 379:111-121|
|Almodovar, Karinna; Iams, Wade T; Meador, Catherine B et al. (2018) Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse. J Thorac Oncol 13:112-123|
|Rakovitch, E; Gray, R; Baehner, F L et al. (2018) Refined estimates of local recurrence risks by DCIS score adjusting for clinicopathological features: a combined analysis of ECOG-ACRIN E5194 and Ontario DCIS cohort studies. Breast Cancer Res Treat 169:359-369|
|Du, Zhenfang; Lovly, Christine M (2018) Mechanisms of receptor tyrosine kinase activation in cancer. Mol Cancer 17:58|
|Pillai, Rathi N; Behera, Madhusmita; Owonikoko, Taofeek K et al. (2018) Comparison of the toxicity profile of PD-1 versus PD-L1 inhibitors in non-small cell lung cancer: A systematic analysis of the literature. Cancer 124:271-277|
|Childress, Merrida A; Himmelberg, Stephen M; Chen, Huiqin et al. (2018) ALK Fusion Partners Impact Response to ALK Inhibition: Differential Effects on Sensitivity, Cellular Phenotypes, and Biochemical Properties. Mol Cancer Res 16:1724-1736|
|Garg, Madhur K; Zhao, Fengmin; Sparano, Joseph A et al. (2017) Cetuximab Plus Chemoradiotherapy in Immunocompetent Patients With Anal Carcinoma: A Phase II Eastern Cooperative Oncology Group-American College of Radiology Imaging Network Cancer Research Group Trial (E3205). J Clin Oncol 35:718-726|
|Pillai, Rathi N; Behera, Madhusmita; Berry, Lynne D et al. (2017) HER2 mutations in lung adenocarcinomas: A report from the Lung Cancer Mutation Consortium. Cancer 123:4099-4105|
|Belinsky, Steven A; Leng, Shuguang; Wu, Guodong et al. (2017) Gene Methylation Biomarkers in Sputum and Plasma as Predictors for Lung Cancer Recurrence. Cancer Prev Res (Phila) 10:635-640|
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