Prenatal substance exposure continues to be a major public health problem that affects millions of children and places enormous financial and social burdens on society. Little is known about the effects of prenatal cocaine exposure on psychological, developmental, medical or physical outcomes in children entering adolescence. The Maternal Lifestyle Study (MLS) is an interagency collaboration involving the National Institute of Child Health and Human Development and the National Institute on Drug Abuse. MLS is being conducted in four academic centers: The University of Miami, University of Tennessee at Memphis, Wayne State University, and Brown University. MLS is the largest clinical prospective longitudinal study to date of prenatal drug exposure and child outcome. The follow-up cohort includes 658 exposed and 730 comparison children who have been studied through 9 years of age with 75% retention. The MLS study involves a unique population given its multi-site component, racial diversity, and extensive long-term follow up.
One aim i s to determine if prenatal cocaine, or other prenatal drug exposure, results in adverse psychological and developmental outcomes at 12-15 years. These outcomes include substance use (early substance use onset, smoking, alcohol consumption, and substance abuse and addiction), academic and cognitive deficits (e.g., poor school performance), physiological reactivity, antisocial behavior (e.g. delinquency), psychopathology, risk-taking behavior (e.g., adolescent pregnancy, sexually transmitted diseases). The role of protective factors such as positive parenting and peer relationships will also be investigated.
A second aim i s to determine the effects of prenatal cocaine exposure on physical and medical outcomes at 12-15 years. These outcomes include physical growth and medical illness, including hypertension, obesity and metabolic disorder, which may have their origins in fetal life, and may be related to the impact of drug exposure on fetal growth. Additional outcomes include structural teratogenic effects (dysmorphology), and neurological disorders. In addition to being a study of prenatal cocaine exposure, MLS is also a study of children growing up in adverse conditions, providing information on development in typically developing children and children at risk. A thorough understanding of the consequences of prenatal cocaine exposure and associated maternal lifestyles is necessary to the development of treatment and public policy initiatives.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10DA024119-04
Application #
7800371
Study Section
Special Emphasis Panel (ZHD1-DSR-H (05))
Program Officer
Boyce, Cheryl A
Project Start
2007-09-30
Project End
2013-03-31
Budget Start
2010-04-01
Budget End
2013-03-31
Support Year
4
Fiscal Year
2010
Total Cost
$1,314,813
Indirect Cost
Name
Women and Infants Hospital-Rhode Island
Department
Type
DUNS #
069851913
City
Providence
State
RI
Country
United States
Zip Code
02905
Sheinkopf, Stephen J; Tenenbaum, Elena J; Messinger, Daniel S et al. (2017) Maternal and infant affect at 4 months predicts performance and verbal IQ at 4 and 7 years in a diverse population. Dev Sci 20:
Salley, Brenda; Sheinkopf, Stephen J; Neal-Beevers, A Rebecca et al. (2016) Infants' early visual attention and social engagement as developmental precursors to joint attention. Dev Psychol 52:1721-1731
Conradt, Elisabeth; Beauchaine, Theodore; Abar, Beau et al. (2016) Early caregiving stress exposure moderates the relation between respiratory sinus arrhythmia reactivity at 1 month and biobehavioral outcomes at age 3. Psychophysiology 53:83-96
Lagasse, Linda L; Conradt, Elisabeth; Karalunas, Sarah L et al. (2016) Transactional relations between caregiving stress, executive functioning, and problem behavior from early childhood to early adolescence. Dev Psychopathol 28:743-56
Locke, Robin L; Lagasse, Linda L; Seifer, Ronald et al. (2016) Effects of prenatal substance exposure on infant temperament vary by context. Dev Psychopathol 28:309-26
Conradt, Elisabeth; Abar, Beau; Sheinkopf, Stephen et al. (2014) The role of prenatal substance exposure and early adversity on parasympathetic functioning from 3 to 6 years of age. Dev Psychobiol 56:821-35
Conradt, Elisabeth; Lagasse, Linda L; Shankaran, Seetha et al. (2014) Physiological correlates of neurobehavioral disinhibition that relate to drug use and risky sexual behavior in adolescents with prenatal substance exposure. Dev Neurosci 36:306-15
Conradt, Elisabeth; Abar, Beau; Lester, Barry M et al. (2014) Cortisol reactivity to social stress as a mediator of early adversity on risk and adaptive outcomes. Child Dev 85:2279-98
Lester, Barry M; Andreozzi-Fontaine, Lynne; Tronick, Edward et al. (2014) Assessment and evaluation of the high risk neonate: the NICU Network Neurobehavioral Scale. J Vis Exp :
Conradt, Elisabeth; Degarmo, David; Fisher, Phil et al. (2014) The contributions of early adverse experiences and trajectories of respiratory sinus arrhythmia on the development of neurobehavioral disinhibition among children with prenatal substance exposure. Dev Psychopathol 26:901-16

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