This proposal is for the University of Alabama at Birmingham Clinical Center to continue to annually examine the 127 currently enrolled COSMICC participants (only 5 subjects are lost to follow-up since enrollment in 1997-98) for an additional 5 yrs (total follow-up, 14 yrs) following the COSMICC2 protocol. The data collected from this center will be used to address the specific aims described in more detail in the Chair application and summarized briefly here: 1) to use mathematical functions (the Gompertz function and others) to model myopia progression in the 58% of COSMICC subjects with progressing myopia and to develop predictive models and test hypotheses based on previously identified risk factors (age, ethnicity, parental myopia);2) to test 4 hypotheses related to environmental risk factors for myopia progression and stabilization and axial elongation in this well-characterized cohort of myopes;and 3) to test three hypotheses related to risk factors for the development of myopia-related changes in IOP, CCT and macular thickness in COSMICC subjects. The high prevalence of myopia (25% of the US adult population) and its prominence as a public health problem (risk factor for conditions that can cause vision loss and blindness) emphasize the importance of gaining increased understanding of mechanisms underlying progression and eventual stabilization, so that in the future myopia might be limited to low levels. Better understanding of the factors predictive of myopia progression and stabilization also will help guide selection and timing of interventions as well as target those groups that may benefit the most from treatment.

National Institute of Health (NIH)
National Eye Institute (NEI)
Cooperative Clinical Research--Cooperative Agreements (U10)
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Study Section
Special Emphasis Panel (ZEY1-VSN (05))
Program Officer
Everett, Donald F
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University of Alabama Birmingham
Other Health Professions
Schools of Optometry/Ophthalmol
United States
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Deng, Li; Gwiazda, Jane; Manny, Ruth E et al. (2014) Limited change in anisometropia and aniso-axial length over 13 years in myopic children enrolled in the Correction of Myopia Evaluation Trial. Invest Ophthalmol Vis Sci 55:2097-105
Scheiman, Mitchell; Zhang, Qinghua; Gwiazda, Jane et al. (2014) Visual activity and its association with myopia stabilisation. Ophthalmic Physiol Opt 34:353-61
Gwiazda, Jane; Deng, Li; Manny, Ruth et al. (2014) Seasonal variations in the progression of myopia in children enrolled in the correction of myopia evaluation trial. Invest Ophthalmol Vis Sci 55:752-8
Harb, Elise; Hyman, Leslie; Fazzari, Melissa et al. (2012) Factors associated with macular thickness in the COMET myopic cohort. Optom Vis Sci 89:620-31
Gwiazda, Jane; Deng, Li; Dias, Lynette et al. (2011) Association of education and occupation with myopia in COMET parents. Optom Vis Sci 88:1045-53
Marsh-Tootle, Wendy L; Dong, Li Ming; Hyman, Leslie et al. (2009) Myopia Progression in Children Wearing Spectacles vs. Switching to Contact Lenses. Optom Vis Sci :
Gwiazda, Jane; Hyman, Leslie; Dong, Li Ming et al. (2007) Factors associated with high myopia after 7 years of follow-up in the Correction of Myopia Evaluation Trial (COMET) Cohort. Ophthalmic Epidemiol 14:230-7
Kurtz, Daniel; Hyman, Leslie; Gwiazda, Jane E et al. (2007) Role of parental myopia in the progression of myopia and its interaction with treatment in COMET children. Invest Ophthalmol Vis Sci 48:562-70
Hyman, Leslie; Gwiazda, Jane; Hussein, Mohamed et al. (2005) Relationship of age, sex, and ethnicity with myopia progression and axial elongation in the correction of myopia evaluation trial. Arch Ophthalmol 123:977-87
Kowalski, Patricia M; Wang, Ying; Owens, Robert E et al. (2005) Adaptability of myopic children to progressive addition lenses with a modified fitting protocol in the Correction of Myopia Evaluation Trial (COMET). Optom Vis Sci 82:328-37

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