The detrimental effects of uncorrected astigmatism on visual development are well documented: blur induced by uncorrected astigmatism results in visual deficits that persist despite optical correction. Partnership with the Tohono O'odham Nation, a Native American tribe with a high prevalence of high astigmatism has allowed researchers to conduct large-scale studies of preschool- and school-aged children with high astigmatism. However, little is known about the development of astigmatism and astigmatism- related amblyopia prior to age 3 years. The goals of the present study are: Goal 1. To document developmental changes in astigmatism and aberrations in infants and young children from a population with a high prevalence of high astigmatism. Goal 2. To determine the relation between quality of visual experience (quality of visual input) in astigmatic and non-astigmatic infants and toddlers and visual development (normal and abnormal/amblyopic). Goal 3. To determine the relation between spherical aberration and coma and corrected visual acuity in young children with and without high astigmatism. Goal 4. To determine the effectiveness of eyeglass treatment of astigmatism-related amblyopia in young children. The proposed study will provide unique and valuable information on the development of astigmatism and aberrations and their effects on visual development, will generate important clinical information to aid in the development of guidelines for treatment and prevention of astigmatism-related amblyopia in infancy and early childhood, and will provide a valuable public health service for a population whose children are at increased risk for the development of amblyopia.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10EY013153-08
Application #
7266215
Study Section
Special Emphasis Panel (ZEY1-VSN (04))
Program Officer
Everett, Donald F
Project Start
2000-09-15
Project End
2010-07-31
Budget Start
2007-08-01
Budget End
2008-07-31
Support Year
8
Fiscal Year
2007
Total Cost
$687,103
Indirect Cost
Name
University of Arizona
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Harvey, Erin M; Leonard-Green, Tina K; Mohan, Kathleen M et al. (2017) Interrater and Test-Retest Reliability of the Beery Visual-Motor Integration in Schoolchildren. Optom Vis Sci 94:598-605
Mohan, Kathleen M; Miller, Joseph M; Harvey, Erin M et al. (2016) Assessment of Grating Acuity in Infants and Toddlers Using an Electronic Acuity Card: The Dobson Card. J Pediatr Ophthalmol Strabismus 53:56-9
Harvey, Erin M; Miller, Joseph M; Twelker, J Daniel et al. (2016) Reading Fluency in School-Aged Children with Bilateral Astigmatism. Optom Vis Sci 93:118-25
Davis, Amy L; Harvey, Erin M; Twelker, J Daniel et al. (2016) Convergence Insufficiency, Accommodative Insufficiency, Visual Symptoms, and Astigmatism in Tohono O'odham Students. J Ophthalmol 2016:6963976
Miller, Joseph M; Harvey, Erin M; Schwiegerling, Jim (2015) Higher-order aberrations and best-corrected visual acuity in Native American children with a high prevalence of astigmatism. J AAPOS 19:352-7.e1
Harvey, Erin M; Miller, Joseph M; Twelker, J Daniel et al. (2015) Longitudinal change and stability of refractive, keratometric, and internal astigmatism in childhood. Invest Ophthalmol Vis Sci 56:190-8
Crescioni, Mabel; Miller, Joseph M; Harvey, Erin M (2015) Accuracy of the Spot and Plusoptix photoscreeners for detection of astigmatism. J AAPOS 19:435-40
Crescioni, Mabel; Messer, Dawn H; Warholak, Terri L et al. (2014) Rasch analysis of the Student Refractive Error and Eyeglass Questionnaire. Optom Vis Sci 91:624-33
Harvey, Erin M; Miller, Joseph M; Schwiegerling, Jim et al. (2013) Developmental changes in anterior corneal astigmatism in Tohono O'odham Native American infants and children. Ophthalmic Epidemiol 20:102-8
Harvey, Erin M; Miller, Joseph M; Schwiegerling, Jim (2013) Utility of an open field Shack-Hartmann aberrometer for measurement of refractive error in infants and young children. J AAPOS 17:494-500

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