Abstract

Infection with C. trachomatis has decreased substantially in trachoma endemic areas following repeated annual mass drug administration with azithromycin, although not as rapidly as anticipated. We propose to conduct a clinical trial to determine the added benefit for communities, which are now at low levels of infection, of a program to identify and treat new families who came after mass treatment, and travelers who return to the community, as they could be the source of re-emergent infection. The proportion of communities who are able to stop mass treatment will be compared in the group of communities randomized to mass treatment plus the newcomer treatment program compared to the communities randomized to mass treatment alone.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
3U10EY022584-01S1
Application #
8536996
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Program Officer
Everett, Donald F
Project Start
2012-09-01
Project End
2016-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
1
Fiscal Year
2012
Total Cost
$79,211
Indirect Cost
$23,824

  Institution

Name
Johns Hopkins University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

West, Sheila K; Munoz, Beatriz; Kaur, Hemjot et al. (2018) Longitudinal change in the serology of antibodies to Chlamydia trachomatis pgp3 in children residing in a trachoma area. Sci Rep 8:3520
Sonoda, Takuma; Lee, Seul Ki; Birnbaumer, Lutz et al. (2018) Melanopsin Phototransduction Is Repurposed by ipRGC Subtypes to Shape the Function of Distinct Visual Circuits. Neuron 99:754-767.e4
West, Sheila K; Munoz, Beatriz; Mkocha, Harran et al. (2017) Treating village newcomers and travelers for trachoma: Results from ASANTE cluster randomized trial. PLoS One 12:e0178595
Zambrano, Andrea I; Muñoz, Beatriz E; Mkocha, Harran et al. (2017) Measuring Trachomatous Inflammation-Intense (TI) When Prevalence Is Low Provides Data on Infection With Chlamydia trachomatis. Invest Ophthalmol Vis Sci 58:997-1000
Cox, Jacob T; Kasubi, Mabula J; Muñoz, Beatriz E et al. (2017) Trachomatous Scarring and Infection With Non-Chlamydia Trachomatis Bacteria in Women in Kongwa, Tanzania. Invest Ophthalmol Vis Sci 58:3249-3253
Cox, Jacob T; Mkocha, Harran; Munoz, Beatriz et al. (2017) Trachomatous scarring among children in a formerly hyper-endemic district of Tanzania. PLoS Negl Trop Dis 11:e0006085
Ervin, Ann-Margret; Mkocha, Harran; Munoz, Beatriz et al. (2016) Surveillance and Azithromycin Treatment for Newcomers and Travelers Evaluation (ASANTE) Trial: Design and Baseline Characteristics. Ophthalmic Epidemiol 23:347-353
Dize, L; Gaydos, C A; Quinn, T C et al. (2015) Stability of Chlamydia trachomatis on storage of dry swabs for accurate detection by nucleic acid amplification tests. J Clin Microbiol 53:1046-7
Zambrano, Andrea I; Muñoz, Beatriz E; Mkocha, Harran et al. (2015) Exposure to an Indoor Cooking Fire and Risk of Trachoma in Children of Kongwa, Tanzania. PLoS Negl Trop Dis 9:e0003774
Dize, L; West, S K; Mkocha, H et al. (2015) Evaluation of pooled ocular and vaginal swabs by the Cepheid GeneXpert CT/NG assay for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae compared to the GenProbe Aptima Combo 2 Assay. Diagn Microbiol Infect Dis 81:102-4

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