The Maternal-Fetal Medicine Division of the University of Alabama at Birmingham (UAB) submits this application to renew our participation as a clinical center of the Eunice Kennedy Shriver NICHD Maternal- Fetal Medicine Units (MFMU) Network. We present our center's current record of exceptional performance and specify new attributes and plans to increase our contributions to the Network's goals of investigating major problems in clinical obstetrics, particularly those related to low birth weight, prematurity, and medical complications of pregnancy. We have a well-established research infrastructure and extensive experience in performing relevant clinical trials both within and outside the MFMU Network. As a Network participating center over the last four 5-year cycles, UAB has played a leadership role in providing research direction for the Network at the Steering Committee and sub-committee levels, contributed efficiently to the conduct of Network trials, and participated significantly in the presentation and publication of data generated by these trials. Among 28 clinical centers in the history of the Network, a UAB investigator has first-authored approximately 25% of 180 current MFMU Network publications. Of 360 total Network presentations at national meetings, a UAB investigator presented 22%. Current members of the UAB investigative team have accumulated well over 150 person-years experience of active participation in or support of MFMU research projects. Alan Tita, MD, PhD and William Andrews, PhD, MD will continue as Principal Investigator and Alternate. The team includes two previous site PI's and 5 members who have served as Network protocol chairpersons or Subcommittee members. Finally on the basis of patient recruitment, protocol adherence, retention and follow-up, data quality, and study start-up time, the MFMU Network Data Coordinating Center ranked us #1 or #2 among the participating centers 77% (10/13) of the time (#1 overall, 58% of the time). If successful in this competitive renewal application, we will marshal our facilities, equipment, data management systems (including our electronic perinatal record system), recruitment resources, strong investigative team and trained personnel even more to develop and implement MFMU Network protocols and projects. We believe that we remain well positioned for competitive renewal as an NICHD MFMU Network center for the next five years.

Public Health Relevance

By continuing to participate in this ongoing multicenter collaborative research program, UAB researchers will help discover new and useful methods to treat and/or prevent major public health problems affecting pregnant women and their infants. These problems include those directly related to pregnancy such as preterm birth and preeclampsia, as well as medical complications coinciding with pregnancy such as diabetes and chronic hypertension.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
2U10HD027869-22
Application #
8080622
Study Section
Special Emphasis Panel (ZHD1-DRG-D (50))
Program Officer
Spong, Catherine
Project Start
1991-04-01
Project End
2016-03-31
Budget Start
2011-04-01
Budget End
2012-03-31
Support Year
22
Fiscal Year
2011
Total Cost
$293,000
Indirect Cost
Name
University of Alabama Birmingham
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Varner, Michael W; Rice, Madeline Murguia; Landon, Mark B et al. (2017) Pregnancies After the Diagnosis of Mild Gestational Diabetes Mellitus and Risk of Cardiometabolic Disorders. Obstet Gynecol 129:273-280
Tita, Alan T N; Lai, Yinglei; Landon, Mark B et al. (2017) Predictive Characteristics of Elevated 1-Hour Glucose Challenge Test Results for Gestational Diabetes. Am J Perinatol 34:1464-1469
Chauhan, Suneet P; Rice, Madeline Murguia; Grobman, William A et al. (2017) Neonatal Morbidity of Small- and Large-for-Gestational-Age Neonates Born at Term in Uncomplicated Pregnancies. Obstet Gynecol 130:511-519
Casey, Brian M; Thom, Elizabeth A; Peaceman, Alan M et al. (2017) Treatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy. N Engl J Med 376:815-825
Yee, Lynn M; Costantine, Maged M; Rice, Madeline Murguia et al. (2017) Racial and Ethnic Differences in Utilization of Labor Management Strategies Intended to Reduce Cesarean Delivery Rates. Obstet Gynecol 130:1285-1294
Silver, Robert M; Myatt, Leslie; Hauth, John C et al. (2017) Cell-Free Total and Fetal DNA in First Trimester Maternal Serum and Subsequent Development of Preeclampsia. Am J Perinatol 34:191-198
Salazar, Ashley; Tolivaisa, Susan; Allard, Donna et al. (2016) What we have learned about best practices for recruitment and retention in multicenter pregnancy studies. Semin Perinatol 40:321-7
Gyamfi-Bannerman, Cynthia; Thom, Elizabeth A; Blackwell, Sean C et al. (2016) Antenatal Betamethasone for Women at Risk for Late Preterm Delivery. N Engl J Med 374:1311-20
Manuck, Tracy A; Rice, Madeline Murguia; Bailit, Jennifer L et al. (2016) Preterm neonatal morbidity and mortality by gestational age: a contemporary cohort. Am J Obstet Gynecol 215:103.e1-103.e14
Caritis, Steve N; Feghali, Maisa N; Grobman, William A et al. (2016) What we have learned about the role of 17-alpha-hydroxyprogesterone caproate in the prevention of preterm birth. Semin Perinatol 40:273-80

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