In 1986, the National Institute of Child Health and Human Development created the Maternal-Fetal Medicine Units (MFMU) Network, consisting of a number of major academic clinical centers, a data coordinating center, and the Institute itself. The purpose ofthe Network was to conduct clinical research aimed at reducing the risk of adverse pregnancy and infant outcome with the ultimate goal of contributing a body of well-conducted studies on which to base medical decisions in perinatal medicine. At present, the MFMU Networkis planning, conducting and analyzingmultiple randomized clinical trials and observational studies in various aspects of maternal-fetal medicine such as preterm birth prevention, prediction and prevention of preeclampsia, measures of obstetrical safety and the management of pregnant women with potential risk factors such as subclinical hypothyroidism. The GeorgeWashington UniversityBiostatistics Center proposes to continue to serve as the data coordinating center for the Network. Our purpose is to provide expertise and support in study design, study conduct and statistical analysis. We will provide statistical leadership in the design ofeach research study and in the preparation of interim and final analyses. We will prepare study documents, including protocols, manuals of operations and data forms, and we will continueto provide a comprehensivedata processing system including distributed, web and central data entry, data base management and data quality control. We will assist investigators in the preparation of manuscripts and abstracts from study results and wewill prepare the final dataset for sharing per MFMU Networkpolicy. We will also provide administrative support such as arrangement of logistical services for provision of study drugs and laboratory assays, maintenance of the MFMU Networkwebsite, coordination of meetings, training sessions and outcome reviews. Wewill manage resources effectively and creatively, so that we can start new studies in a timely manner. The relevance ofthe proposed research to public health is clear and direct. The results ofthe Network studies potentially can benefit pregnant women and their children worldwide;for example, by finding methods to screen for problems in pregnancy, by finding maternal treatments that improve children's health, and especially by finding treatments that can help lessen the problem ofbabies being born too early.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Cooperative Clinical Research--Cooperative Agreements (U10)
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Special Emphasis Panel (ZHD1-DSR-A (03))
Program Officer
Ilekis, John V
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George Washington University
Biostatistics & Other Math Sci
Schools of Arts and Sciences
United States
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Bloom, Steven L; Belfort, Michael; Saade, George et al. (2016) What we have learned about intrapartum fetal monitoring trials in the MFMU Network. Semin Perinatol 40:307-17
Cheong-See, Fiona; Schuit, Ewoud; Arroyo-Manzano, David et al. (2016) Prospective risk of stillbirth and neonatal complications in twin pregnancies: systematic review and meta-analysis. BMJ 354:i4353
Salazar, Ashley; Tolivaisa, Susan; Allard, Donna et al. (2016) What we have learned about best practices for recruitment and retention in multicenter pregnancy studies. Semin Perinatol 40:321-7
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Bailit, Jennifer L; Grobman, William A; Rice, Madeline Murguia et al. (2016) Evaluation of delivery options for second-stage events. Am J Obstet Gynecol 214:638.e1-638.e10
Rice, Madeline Murguia; Landon, Mark B; Varner, Michael W et al. (2016) Pregnancy-Associated Hypertension in Glucose-Intolerant Pregnancy and Subsequent Metabolic Syndrome. Obstet Gynecol 127:771-9

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