Columbia University has been an active contributor to the MFMU since 2001 and is now submitting a competitive renewal. They presently are ranked fourth overall in participation and have routinely recruited in the top half of all centers. Since the last application, the Division has grown to 17 MFM specialists, 10 of which are available to the network;all of whom have protected research time. The faculty have extensive experience in multicentered collaborative research;including protocol design and analysis. Ronald Wapner, MD has been recruited to be the PI of this application. He was previously PI at both Drexel and Thomas Jefferson University. Under his direction these sites routinely ranked among the top 5 centers. Drexel is presently ranked second. A concept evaluating the relationship of maternal genotype to preterm birth has been developed and demonstrates the center's capabilities at protocol development and their understanding of the value of a large collaborative network. This trial specifically evaluates variations in the (32adrenergic receptor and the impact on preterm birth and the response to tocolysis. Interactions between other genotypes suggested to increase preterm birth and specific demographic and environmental variables will be evaluated. olumbia has the research infrastructure to be successful as a participant in the MFMU which includes experienced research nurses, a perinatal database, and a delivery service of over 6000 deliveries/yr in a single institution. Additional resources available include perinatal epidemiology, basic science expertise, and :ormal relationships with community hospitals providing access to additional patients if and when necessary.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10HD040485-11
Application #
8020043
Study Section
Special Emphasis Panel (ZHD1-MCHG-B (23))
Program Officer
Spong, Catherine
Project Start
2001-04-01
Project End
2011-03-31
Budget Start
2010-12-01
Budget End
2011-03-31
Support Year
11
Fiscal Year
2011
Total Cost
$91,916
Indirect Cost
Name
Columbia University (N.Y.)
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Gyamfi-Bannerman, Cynthia; Thom, Elizabeth A; Blackwell, Sean C et al. (2016) Antenatal Betamethasone for Women at Risk for Late Preterm Delivery. N Engl J Med 374:1311-20
Caritis, Steve N; Feghali, Maisa N; Grobman, William A et al. (2016) What we have learned about the role of 17-alpha-hydroxyprogesterone caproate in the prevention of preterm birth. Semin Perinatol 40:273-80
Yee, Lynn M; Sandoval, Grecio; Bailit, Jennifer et al. (2016) Maternal and Neonatal Outcomes With Early Compared With Delayed Pushing Among Nulliparous Women. Obstet Gynecol 128:1039-1047
Landon, Mark B; Grobman, William A; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network (2016) What We Have Learned About Trial of Labor After Cesarean Delivery from the Maternal-Fetal Medicine Units Cesarean Registry. Semin Perinatol 40:281-6
Froehlich, Rosemary J; Sandoval, Grecio; Bailit, Jennifer L et al. (2016) Association of Recorded Estimated Fetal Weight and Cesarean Delivery in Attempted Vaginal Delivery at Term. Obstet Gynecol 128:487-94
Manuck, Tracy A; Rice, Madeline Murguia; Bailit, Jennifer L et al. (2016) Preterm neonatal morbidity and mortality by gestational age: a contemporary cohort. Am J Obstet Gynecol 215:103.e1-103.e14
Bloom, Steven L; Belfort, Michael; Saade, George et al. (2016) What we have learned about intrapartum fetal monitoring trials in the MFMU Network. Semin Perinatol 40:307-17
Salazar, Ashley; Tolivaisa, Susan; Allard, Donna et al. (2016) What we have learned about best practices for recruitment and retention in multicenter pregnancy studies. Semin Perinatol 40:321-7
Rice, Madeline Murguia; Landon, Mark B; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units (MFMU) Network (2016) What we have learned about treating mild gestational diabetes mellitus. Semin Perinatol 40:298-302
Blackwell, Sean C; Landon, Mark B; Mele, Lisa et al. (2016) Relationship Between Excessive Gestational Weight Gain and Neonatal Adiposity in Women With Mild Gestational Diabetes Mellitus. Obstet Gynecol 128:1325-1332

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