The Parkinson's disease neuroprotection clinical trial is currently trying to determine if creatine is neuroprotective in the treatment of Parkinson's disease. As part of this multicenter trial, we have enrolled 21 patients and are currently followin 20 of these patients. We plan to continue to retain and follow these patients in the trial for the next 3 years or to completion (see specific aims section).

Agency
National Institute of Health (NIH)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10NS044415-13
Application #
8601904
Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Moy, Claudia S
Project Start
Project End
Budget Start
Budget End
Support Year
13
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Rbhs-Robert Wood Johnson Medical School
Department
Neurology
Type
Schools of Medicine
DUNS #
City
Piscataway
State
NJ
Country
United States
Zip Code
08854
Tilley, Barbara C; Mainous 3rd, Arch G; Elm, Jordan J et al. (2012) A randomized recruitment intervention trial in Parkinson's disease to increase participant diversity: early stopping for lack of efficacy. Clin Trials 9:188-97
Elble, Rodger J; Suchowersky, Oksana; Shaftman, Stephanie et al. (2010) Impact of belief in neuroprotection on therapeutic intervention in Parkinson's disease. Mov Disord 25:1082-6
Schneider, Jay S; Elm, Jordan J; Parashos, Sotirios A et al. (2010) Predictors of cognitive outcomes in early Parkinson disease patients: The National Institutes of Health Exploratory Trials in Parkinson Disease (NET-PD) experience. Parkinsonism Relat Disord 16:507-12
Yang, Chengwu; Garrett-Mayer, Elizabeth; Schneider, Jay S et al. (2009) Repeatable battery for assessment of neuropsychological status in early Parkinson's disease. Mov Disord 24:1453-60
Evatt, Marian L; Chaudhuri, K Ray; Chou, Kelvin L et al. (2009) Dysautonomia rating scales in Parkinson's disease: sialorrhea, dysphagia, and constipation--critique and recommendations by movement disorders task force on rating scales for Parkinson's disease. Mov Disord 24:635-46
Mauldin, Patrick D; Guimaraes, Paulo; Albin, Roger L et al. (2008) Optimal frequency for measuring health care resource utilization in Parkinson's disease using participant recall: the FS-TOO resource utilization substudy. Clin Ther 30:1553-7
NINDS NET-PD Investigators (2008) A pilot clinical trial of creatine and minocycline in early Parkinson disease: 18-month results. Clin Neuropharmacol 31:141-50
Tilley, Barbara C; Galpern, Wendy R (2007) Screening potential therapies: lessons learned from new paradigms used in Parkinson disease. Stroke 38:800-3
Elm, Jordan J; Kamp, Cornelia; Tilley, Barbara C et al. (2007) Self-reported adherence versus pill count in Parkinson's disease: the NET-PD experience. Mov Disord 22:822-7
NINDS NET-PD Investigators (2007) A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease. Neurology 68:20-8

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