Abstract

A major goal of research in Parkinson disease (PD) is to develop treatments that will slow or forestall the progression of this common neurodegenerative disease, which afflicts at least 500,000 people in the United States. Southern Illinois University School of Medicine (SIUSM) has been a member of the NINDS Exploratory Trials in Parkinson disease (NET-PD) network since its inception. SIUSM was a productive site in the initial two futility studies of creatine, coenzyme Q10, minocycline, and GPI 1485 and is a high-enrolling site for the ongoing Phase 3 randomized, double-blinded and placebo-controlled clinical trial of creatine (LS1). We are also a site for the futility trial of pioglitazone (FS-ZONE). This application is a request for continued funding as a participating center.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
2U10NS044450-11
Application #
8460675
Study Section
Special Emphasis Panel (ZNS1-SRB-B (34))
Program Officer
Moy, Claudia S
Project Start
2002-09-30
Project End
2015-11-30
Budget Start
2013-01-01
Budget End
2013-11-30
Support Year
11
Fiscal Year
2013
Total Cost
$71,892
Indirect Cost
$22,482

  Institution

Name
Southern Illinois University School of Medicine
Department
Neurology
Type
Schools of Medicine
DUNS #
038415006
City
Springfield
State
IL
Country
United States
Zip Code
62794

  Publications

Wills, Anne-Marie A; Elm, Jordan J; Ye, Rong et al. (2016) Cognitive function in 1736 participants in NINDS Exploratory Trials in PD Long-term Study-1. Parkinsonism Relat Disord 33:127-133
Wills, Anne-Marie A; Pérez, Adriana; Wang, Jue et al. (2016) Association Between Change in Body Mass Index, Unified Parkinson's Disease Rating Scale Scores, and Survival Among Persons With Parkinson Disease: Secondary Analysis of Longitudinal Data From NINDS Exploratory Trials in Parkinson Disease Long-term Study 1 JAMA Neurol 73:321-8
Elble, Rodger J (2014) Mechanisms of deep brain stimulation for essential tremor. Brain 137:4-6
Kaul, Siddharth; Elble, Rodger J (2014) Impaired pentagon drawing is an early predictor of cognitive decline in Parkinson's disease. Mov Disord 29:427-8
Elble, Rodger J (2013) What is essential tremor? Curr Neurol Neurosci Rep 13:353
Elble, Rodger; Comella, Cynthia; Fahn, Stanley et al. (2012) Reliability of a new scale for essential tremor. Mov Disord 27:1567-9
Elm, Jordan J; NINDS NET-PD Investigators (2012) Design innovations and baseline findings in a long-term Parkinson's trial: the National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson's Disease Long-Term Study-1. Mov Disord 27:1513-21
Mauldin, Patrick D; Guimaraes, Paulo; Albin, Roger L et al. (2008) Optimal frequency for measuring health care resource utilization in Parkinson's disease using participant recall: the FS-TOO resource utilization substudy. Clin Ther 30:1553-7