To successfully complete the NET-PD's current ongoing clinical trial. Summary: The Georgia Health Sciences University (GHSU) Movement Disorders Clinic (MDC) is a uniquely qualified and established clinical center for the proposed continuation of a large Phase III, randomized, double-blinded, placebo-controlled clinical trial, which seeks to evaluate the neuroprotective potential of creatine compared with placebo in over 1700 patients. GHSU is seeking support so as to continue all patient follow-up activities necessary for the successful completion of the creatine trial. Follow-up is expected to be completed in 2015. This project is aimed to evaluate the neuroprotective potential of a pharmacological agent designed to slow the progression of PD;the goal set forth by NINDS upon initiation of the NET-PD program. Long-Term Objectives: 1. To delay the progression of PD through the use of medications while maintaining quality of life. 2. Discover indicators of those susceptible to PD and prevent or delay onset of the disease. 3. Ultimately, find a cure for PD.

Public Health Relevance

Parkinson's disease (PD) affects at least half a million Americans. This number is expected to increase over the coming decades as the population ages. This project seeks to find an effective neuroprotective agent, which would slow the progression of PD and substantially reduce PD-related disability for hundreds of thousands of Americans.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
2U10NS044464-11
Application #
8460663
Study Section
Special Emphasis Panel (ZNS1-SRB-B (34))
Program Officer
Moy, Claudia S
Project Start
2002-09-30
Project End
2015-11-30
Budget Start
2013-01-01
Budget End
2013-11-30
Support Year
11
Fiscal Year
2013
Total Cost
$38,952
Indirect Cost
$27,242
Name
Georgia Regents University
Department
Neurology
Type
Schools of Medicine
DUNS #
966668691
City
Augusta
State
GA
Country
United States
Zip Code
30912