We propose to create the Boston NETT Site, a team of hospitals and EMS agencies in Boston that will serve as a top-enrolling site and vibrant contributor to the NETT Network. Our group includes all adult Level I trauma centers in the city of Boston. All hospitals have a proven track record of successful management and performance of clinical trials. In particular, all hospitals have an established research infrastructure that performs ongoing clinical research in both emergency and neurology departments, which can be leveraged to meet the needs of NETT. Principal investigator Joshua N. Goldstein, MD, PhD, and Co-investigator Jonathan Rosand, MD, MS bring a complementary set of skills in managing successful clinical research programs, membership on Steering Committees, and positions of national leadership in their fields. Our team includes investigators in neurology and emergency medicine with nationally recognized expertise managing the difficult task of enrolling patients in the emergency setting. Strengths of the Boston NETT Group include 1) the close personal and professional ties between multiple investigators, as shown by a history of successful collaborative research projects;2) a large population from a major metropolitan area that spans the full range of neurologic disorders;3) talented teams of site Investigators with track records of scientific achievement and innovation, as well as subject recruitment and data management in multicenter trials;4) an existing research infrastructure, funded by a range of sources including NINDS, which can be leveraged to meet the needs of NETT;5) numerous existing clinical research programs including the Neurology Clinical Trials Unit, The Harvard Catalyst Clinical and Translational Science Award (CTSA) program, the BU Clinical and Translational Science (CTSA) Institute, the Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS) Network, the NeuroNEXT Network, and the NeuroNEXT Clinical Coordinating Center;6) close integration with pre-hospital services, including Boston EMS and Boston Medflight. Overall, the Boston NETT Group has the resources, vision, and enthusiasm to enhance the ongoing success of the NETT Network.

Public Health Relevance

The Boston NETT Site will be comprised of Massachusetts General Hospital (MGH), Brigham &Women's Hospital (BWH), Beth Israel Deaconess Medical Center (BIDMC), Boston Medical Center (BMC), and Children's Hospital Boston (CHB), all organizations with internationally recognized patient care and clinical research programs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10NS080369-02
Application #
8528746
Study Section
Special Emphasis Panel (ZNS1-SRB-N (01))
Program Officer
Janis, Scott
Project Start
2012-09-01
Project End
2017-05-31
Budget Start
2013-08-01
Budget End
2014-05-31
Support Year
2
Fiscal Year
2013
Total Cost
$324,071
Indirect Cost
$130,899
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Dowlatshahi, Dar; Brouwers, H Bart; Demchuk, Andrew M et al. (2016) Predicting Intracerebral Hemorrhage Growth With the Spot Sign: The Effect of Onset-to-Scan Time. Stroke 47:695-700
Morotti, Andrea; Jessel, Michael J; Brouwers, H Bart et al. (2016) CT Angiography Spot Sign, Hematoma Expansion, and Outcome in Primary Pontine Intracerebral Hemorrhage. Neurocrit Care 25:79-85
Brouwers, H Bart; Battey, Thomas W K; Musial, Hayley H et al. (2015) Rate of Contrast Extravasation on Computed Tomographic Angiography Predicts Hematoma Expansion and Mortality in Primary Intracerebral Hemorrhage. Stroke 46:2498-503
Brouwers, H Bart; Chang, Yuchiao; Falcone, Guido J et al. (2014) Predicting hematoma expansion after primary intracerebral hemorrhage. JAMA Neurol 71:158-64
Wright, David W; Yeatts, Sharon D; Silbergleit, Robert et al. (2014) Very early administration of progesterone for acute traumatic brain injury. N Engl J Med 371:2457-66
Alfredo Caceres, J; Greer, David M; Goldstein, Joshua N et al. (2014) Enrollment of research subjects through telemedicine networks in a multicenter acute intracerebral hemorrhage clinical trial: design and methods. J Vasc Interv Neurol 7:34-40