: The University of Pennsylvania Center for Education and Research on Therapeutics (PennCERT) proposes to reinforce and expand its infrastructure, while conducting research and educational programs to advance therapeutics in an even more focused way. The theme of the PennCERT will continue to be infectious diseases (anti-infective therapy) with the following new subthemes (i.e., areas of methodologic focus where we can be a resource for the whole CERT network): 1) pharmacoepidemiology, 2) patient safety, and 3) health information technology. In particular, we propose to: 1. Build on and enhance our research and educational center with its coordinated infrastructure;continue our active participation in the national CERTs program;continue our mini-grant program that funds studies addressing relevant therapeutic questions and pilot studies that support the development of R01 applications;and maintain an impressive series of data resources, accessible to investigators from the PennCERT and other CERTs. 2. Conduct research to improve the underlying evidence base for decisions about the use and effects of anti-infectives. 3. Implement and evaluate interventions aimed at improving the use of anti-infectives in outpatient and especially inpatient settings, locally, regionally, and nationally. 4. Conduct education in research methods, critical appraisal of the medical literature, and therapeutic decisionmaking targeting multiple audiences, including medical students, graduate medical trainees, and health care professionals. 5. Disseminate and translate the results of our work, including publications and presentations: i) for the scientific/professional community;ii) the FDA, AHRQ, other CERTs, etc.;and iii) the public, building on the well-developed dissemination program of the Leonard Davis Institute. New features of the current PennCERT application include new investigators (former PennCERT trainees who have now accepted positions as faculty);investigators added to strengthen our expertise in health economics, biomedical informatics, and spatial modeling;an increased focus on pediatrics, with faculty and a major project planned at Children's Hospital of Philadelphia;an increased focus on research and education intended to develop, implement, and evaluate novel programs for translating evidence on optimal antimicrobial drug practices into everyday practice, particularly in hospital settings;four larger research projects, possible because of the increased resources now available;and an increased flexibility in choice of projects in future years, as earlier projects are completed.

Agency
National Institute of Health (NIH)
Institute
Agency for Healthcare Research and Quality (AHRQ)
Type
Research Demonstration--Cooperative Agreements (U18)
Project #
5U18HS016946-04
Application #
7898829
Study Section
Special Emphasis Panel (ZHS1-HSR-O (01))
Program Officer
Randhawa, Gurvaneet
Project Start
2007-09-01
Project End
2011-08-31
Budget Start
2010-09-01
Budget End
2011-08-31
Support Year
4
Fiscal Year
2010
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Biostatistics & Other Math Sci
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Baillie, Charles A; Epps, Mika; Hanish, Asaf et al. (2014) Usability and impact of a computerized clinical decision support intervention designed to reduce urinary catheter utilization and catheter-associated urinary tract infections. Infect Control Hosp Epidemiol 35:1147-55
Meropol, Sharon B; Localio, A Russell; Metlay, Joshua P (2013) Risks and benefits associated with antibiotic use for acute respiratory infections: a cohort study. Ann Fam Med 11:165-72
Linkin, Darren R; Fishman, Neil O; Shea, Judy A et al. (2013) Public reporting of hospital-acquired infections is not associated with improved processes or outcomes. Infect Control Hosp Epidemiol 34:844-6
Meropol, Sharon B; Metlay, Joshua P (2012) Accuracy of pneumonia hospital admissions in a primary care electronic medical record database. Pharmacoepidemiol Drug Saf 21:659-65
Kronman, Matthew P; Zaoutis, Theoklis E; Haynes, Kevin et al. (2012) Antibiotic exposure and IBD development among children: a population-based cohort study. Pediatrics 130:e794-803
Nachega, Jean B; Marconi, Vincent C; van Zyl, Gert U et al. (2011) HIV treatment adherence, drug resistance, virologic failure: evolving concepts. Infect Disord Drug Targets 11:167-74
Haynes, Kevin; Linkin, Darren R; Fishman, Neil O et al. (2011) Effectiveness of an information technology intervention to improve prophylactic antibacterial use in the postoperative period. J Am Med Inform Assoc 18:164-8
Strom, Brian L; Schinnar, Rita; Bilker, Warren et al. (2010) Randomized clinical trial of a customized electronic alert requiring an affirmative response compared to a control group receiving a commercial passive CPOE alert: NSAID--warfarin co-prescribing as a test case. J Am Med Inform Assoc 17:411-5
Acri, Trisha L; Grossberg, Robert M; Gross, Robert (2010) How long is the right interval for assessing antiretroviral pharmacy refill adherence? J Acquir Immune Defic Syndr 54:e16-8
Margolis, David J; Hoffstad, Ole; Thom, Stephen et al. (2010) The differential effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers with respect to foot ulcer and limb amputation in those with diabetes. Wound Repair Regen 18:445-51

Showing the most recent 10 out of 16 publications