The Dominantly Inherited Alzheimer Network (DIAN), Core B: Clinical is responsible for the protocol development of all clinical operations for the research studies, including participant recruitment, enrollment and protection;performing clinical evaluations including neuropsychometric testing, completing imaging, blood and CSF collections, and offering genetic counseling and testing. The study of dominantly inherited Alzheimer Disease will likely lead to a better understanding of the causes of Alzheimer Disease and potential methods of detecting it at the earliest stages, even before clinical symptoms have begun. This will allow for preventative treatments to be tested. The clinical core will obtain highly sensitive clinical evaluations and neuropsychometric testing to determine the earliest symptoms and progression rates. The clinical core will also obtain imaging studies, blood and cerebral-spinal fluid to measure biomarker changes which may occur before symptoms. The data generated from these studies will be used by DIAN investigators to advance the understanding of the causes of Alzheimer Disease, methods of early detection, and design future preventative treatments.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AG032438-06
Application #
8600216
Study Section
Special Emphasis Panel (ZAG1-ZIJ-1)
Project Start
Project End
2014-06-30
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
6
Fiscal Year
2014
Total Cost
$165,294
Indirect Cost
$57,652
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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Su, Yi; Blazey, Tyler M; Owen, Christopher J et al. (2016) Correction: Quantitative Amyloid Imaging in Autosomal Dominant Alzheimer's Disease: Results from the DIAN Study Group. PLoS One 11:e0163669
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