BIOSPECIMEN CORE - CORE D: ABSTRACT Biomarkers for Older Controls At Risk for Dementia (BIOCARD) STUDY The Biospecimen Core (Core D) is responsible for all aspects of cerebrospinal fluid (CSF) and blood collection, storage, and analysis.
The aims of the Biospecimen Core are:
The specific aims of Biospecimen Core are: (1) Collect, catalog, and store CSF and blood specimens from participants in the BIOCARD study and from patients in the Johns Hopkins CSF Disorders Center (the latter to be used for exploratory analyses). CSF collection will be reinitiated biannually in the BIOCARD cohort, to add to the existing specimens. (2) Perform AlzBio3 assays for CSF A?1-42, total tau, and ptau-181 and an MSD assay for A?1-42 on all newly collected CSF specimens from BIOCARD participants and from well characterized patients in the Johns Hopkins CSF Disorders Center, and compare the validity of the two assays for A?1-42. (3) Examine the utility of new CSF assays as Alzheimer's disease (AD) biomarkers, using samples from patients in the Johns Hopkins CSF Disorders Center for discovery, and from participants in the BIOCARD cohort for validation. These assays will include: (a) a multiplexed assay for inflammatory markers, (b) a proteomics assay for synaptic markers and (c) a metabolomic assay for small molecules.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Research Program--Cooperative Agreements (U19)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5 (M3))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Johns Hopkins University
United States
Zip Code
Onyike, Chiadi U (2016) Psychiatric Aspects of Dementia. Continuum (Minneap Minn) 22:600-14
Gross, Alden L; Mungas, Dan M; Leoutsakos, Jeannie-Marie S et al. (2016) Alzheimer's disease severity, objectively determined and measured. Alzheimers Dement (Amst) 4:159-168
Wennberg, Alexandra M V; Spira, Adam P; Pettigrew, Corinne et al. (2016) Blood glucose levels and cortical thinning in cognitively normal, middle-aged adults. J Neurol Sci 365:89-95
Soldan, Anja; Pettigrew, Corinne; Cai, Qing et al. (2016) Hypothetical Preclinical Alzheimer Disease Groups and Longitudinal Cognitive Change. JAMA Neurol 73:698-705
Pettigrew, Corinne; Soldan, Anja; Zhu, Yuxin et al. (2016) Cortical thickness in relation to clinical symptom onset in preclinical AD. Neuroimage Clin 12:116-22
Mills, Kelly A; Mari, Zoltan; Bakker, Catherine et al. (2016) Gait function and locus coeruleus Lewy body pathology in 51 Parkinson's disease patients. Parkinsonism Relat Disord 33:102-106
Soldan, Anja; Pettigrew, Corinne; Moghekar, Abhay et al. (2016) Computerized Cognitive Tests Are Associated with Biomarkers of Alzheimer's Disease in Cognitively Normal Individuals 10 Years Prior. J Int Neuropsychol Soc 22:968-977
Miller, Michael I; Ratnanather, J Tilak; Tward, Daniel J et al. (2015) Network Neurodegeneration in Alzheimer's Disease via MRI Based Shape Diffeomorphometry and High-Field Atlasing. Front Bioeng Biotechnol 3:54
Soldan, Anja; Pettigrew, Corinne; Lu, Yi et al. (2015) Relationship of medial temporal lobe atrophy, APOE genotype, and cognitive reserve in preclinical Alzheimer's disease. Hum Brain Mapp 36:2826-41
Pettigrew, Corinne; Soldan, Anja; Moghekar, Abhay et al. (2015) Relationship between cerebrospinal fluid biomarkers of Alzheimer's disease and cognition in cognitively normal older adults. Neuropsychologia 78:63-72

Showing the most recent 10 out of 31 publications