ADMINISTRATIVE CORE - CORE A: ABSTRACT The BIOCARD study is a longitudinal, observational study of 349 individuals who were cognitively normal and primarily middle aged (mean age=57.1) at enrollment. Our overall objectives are to further advance the study of preclinical AD by: (1) clarifying the pattern and rate of changes in AD biomarkers (including CSF, MRI, amyloid imaging and blood) and cognition that occur during the earliest phases of AD, (2) maximizing our data by working collaboratively with several research groups who have comparable data, and (3) providing a publicly accessible database, to include biological specimens, for researchers in the field. To accomplish these goals we established 7 Cores. The Administrative Core (Core A) is essential for the overall functioning and coordination of the project.
The specific aims i nclude: (1) oversight and integration of the Cores in the project, (2) facilitation of collaborative research with investigators outside of Johns Hopkins University (JHU), (3) assurance of sound fiscal management, (4) assurance that all aspects of the project comply with local and federal regulations, (5) coordinating external review of the project through meetings of the Scientific Advisory Board and the Resource Allocation Committee, and (6) communicating with the staff of the National Institute on Aging (NIA) consistent with the guidelines of the FOA.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program--Cooperative Agreements (U19)
Project #
2U19AG033655-06
Application #
8740116
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5 (M3))
Project Start
2014-08-15
Project End
2019-03-31
Budget Start
2014-08-15
Budget End
2015-03-31
Support Year
6
Fiscal Year
2014
Total Cost
$162,708
Indirect Cost
$54,655
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Onyike, Chiadi U (2016) Psychiatric Aspects of Dementia. Continuum (Minneap Minn) 22:600-14
Gross, Alden L; Mungas, Dan M; Leoutsakos, Jeannie-Marie S et al. (2016) Alzheimer's disease severity, objectively determined and measured. Alzheimers Dement (Amst) 4:159-168
Wennberg, Alexandra M V; Spira, Adam P; Pettigrew, Corinne et al. (2016) Blood glucose levels and cortical thinning in cognitively normal, middle-aged adults. J Neurol Sci 365:89-95
Soldan, Anja; Pettigrew, Corinne; Cai, Qing et al. (2016) Hypothetical Preclinical Alzheimer Disease Groups and Longitudinal Cognitive Change. JAMA Neurol 73:698-705
Pettigrew, Corinne; Soldan, Anja; Zhu, Yuxin et al. (2016) Cortical thickness in relation to clinical symptom onset in preclinical AD. Neuroimage Clin 12:116-22
Mills, Kelly A; Mari, Zoltan; Bakker, Catherine et al. (2016) Gait function and locus coeruleus Lewy body pathology in 51 Parkinson's disease patients. Parkinsonism Relat Disord 33:102-106
Soldan, Anja; Pettigrew, Corinne; Moghekar, Abhay et al. (2016) Computerized Cognitive Tests Are Associated with Biomarkers of Alzheimer's Disease in Cognitively Normal Individuals 10 Years Prior. J Int Neuropsychol Soc 22:968-977
Miller, Michael I; Ratnanather, J Tilak; Tward, Daniel J et al. (2015) Network Neurodegeneration in Alzheimer's Disease via MRI Based Shape Diffeomorphometry and High-Field Atlasing. Front Bioeng Biotechnol 3:54
Soldan, Anja; Pettigrew, Corinne; Lu, Yi et al. (2015) Relationship of medial temporal lobe atrophy, APOE genotype, and cognitive reserve in preclinical Alzheimer's disease. Hum Brain Mapp 36:2826-41
Pettigrew, Corinne; Soldan, Anja; Moghekar, Abhay et al. (2015) Relationship between cerebrospinal fluid biomarkers of Alzheimer's disease and cognition in cognitively normal older adults. Neuropsychologia 78:63-72

Showing the most recent 10 out of 31 publications