ADMINISTRATIVE CORE - CORE A: ABSTRACT The BIOCARD study is a longitudinal, observational study of 349 individuals who were cognitively normal and primarily middle aged (mean age=57.1) at enrollment. Our overall objectives are to further advance the study of preclinical AD by: (1) clarifying the pattern and rate of changes in AD biomarkers (including CSF, MRI, amyloid imaging and blood) and cognition that occur during the earliest phases of AD, (2) maximizing our data by working collaboratively with several research groups who have comparable data, and (3) providing a publicly accessible database, to include biological specimens, for researchers in the field. To accomplish these goals we established 7 Cores. The Administrative Core (Core A) is essential for the overall functioning and coordination of the project.
The specific aims i nclude: (1) oversight and integration of the Cores in the project, (2) facilitation of collaborative research with investigators outside of Johns Hopkins University (JHU), (3) assurance of sound fiscal management, (4) assurance that all aspects of the project comply with local and federal regulations, (5) coordinating external review of the project through meetings of the Scientific Advisory Board and the Resource Allocation Committee, and (6) communicating with the staff of the National Institute on Aging (NIA) consistent with the guidelines of the FOA.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research Program--Cooperative Agreements (U19)
Project #
2U19AG033655-06
Application #
8740116
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5 (M3))
Project Start
2014-08-15
Project End
2019-03-31
Budget Start
2014-08-15
Budget End
2015-03-31
Support Year
6
Fiscal Year
2014
Total Cost
$162,708
Indirect Cost
$54,655
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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Pettigrew, Corinne; Soldan, Anja; Zhu, Yuxin et al. (2017) Cognitive reserve and cortical thickness in preclinical Alzheimer's disease. Brain Imaging Behav 11:357-367
Mori, Susumu; Kageyama, Yusuke; Hou, Zhipeng et al. (2017) Elucidation of White Matter Tracts of the Human Amygdala by Detailed Comparison between High-Resolution Postmortem Magnetic Resonance Imaging and Histology. Front Neuroanat 11:16
Soldan, Anja; Pettigrew, Corinne; Cai, Qing et al. (2017) Cognitive reserve and long-term change in cognition in aging and preclinical Alzheimer's disease. Neurobiol Aging 60:164-172
Leoutsakos, J-M; Gross, A L; Jones, R N et al. (2016) 'Alzheimer's Progression Score': Development of a Biomarker Summary Outcome for AD Prevention Trials. J Prev Alzheimers Dis 3:229-235

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