Abstract

The Laboratory core under You-Xun Zhang, PhD, will perform laboratory testing mainly in support of Projects 1 and 2. The Core will identify microbiologic causes of endometritis using culture, antigen detection and DNA amplification methods. The laboratory will also grow large batches of Chlamydia for Project 4, and the pathologists in this Core will perform histopathologic and immunohistopathologic analysis of endometrial specimens taken from: women prior to their undergoing in vitro fertilization; women with recurrent miscarriages; and women with acute endometritis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI038515-03
Application #
6235384
Study Section
Project Start
1997-07-01
Project End
1998-06-30
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
3
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118

  Publications

Ketterer, Margaret R; Rice, Peter A; Gulati, Sunita et al. (2016) Desialylation of Neisseria gonorrhoeae Lipooligosaccharide by Cervicovaginal Microbiome Sialidases: The Potential for Enhancing Infectivity in Men. J Infect Dis 214:1621-1628
Agarwal, Sarika; Sebastian, Shite; Szmigielski, Borys et al. (2008) Expression of the gonococcal global regulatory protein Fur and genes encompassing the Fur and iron regulon during in vitro and in vivo infection in women. J Bacteriol 190:3129-39
Sagar, Manish; Wu, Xueling; Lee, Sandra et al. (2006) Human immunodeficiency virus type 1 V1-V2 envelope loop sequences expand and add glycosylation sites over the course of infection, and these modifications affect antibody neutralization sensitivity. J Virol 80:9586-98
Shen, Li; Feng, Xiaogeng; Yuan, Yuan et al. (2006) Selective promoter recognition by chlamydial sigma28 holoenzyme. J Bacteriol 188:7364-77
Sagar, Manish; Kirkegaard, Erin; Lavreys, Ludo et al. (2006) Diversity in HIV-1 envelope V1-V3 sequences early in infection reflects sequence diversity throughout the HIV-1 genome but does not predict the extent of sequence diversity during chronic infection. AIDS Res Hum Retroviruses 22:430-7
Wu, Hsing-Ju; Seib, Kate L; Srikhanta, Yogitha N et al. (2006) PerR controls Mn-dependent resistance to oxidative stress in Neisseria gonorrhoeae. Mol Microbiol 60:401-16
Seib, Kate L; Wu, Hsing-Ju; Kidd, Stephen P et al. (2006) Defenses against oxidative stress in Neisseria gonorrhoeae: a system tailored for a challenging environment. Microbiol Mol Biol Rev 70:344-61
Porter, Edith; Yang, Huixia; Yavagal, Sujata et al. (2005) Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions. Infect Immun 73:4823-33
Wu, Hsing-Ju; Seib, Kate L; Edwards, Jennifer L et al. (2005) Azurin of pathogenic Neisseria spp. is involved in defense against hydrogen peroxide and survival within cervical epithelial cells. Infect Immun 73:8444-8
Seib, Kate L; Simons, Mark P; Wu, Hsing-Ju et al. (2005) Investigation of oxidative stress defenses of Neisseria gonorrhoeae by using a human polymorphonuclear leukocyte survival assay. Infect Immun 73:5269-72

Showing the most recent 10 out of 64 publications