PILOT PROJECTS CORE for Influenza Immunity: Protective Mechanisms against a Pandemic Respiratory Virus. The purpose of the Pilot Projects Core is to support investigators new to human immunology studies or with novel ideas or technologies to be applied to human immunological questions. These small grants will provide funds to obtain pilot data as a foundation for subsequent application for extramural funding.
The specific aims of this Core are: l.A.To solicit proposals on an annual basis in the Stanford research community for pilot projects related to human immunology. l.B.To review these proposals and to award seed grants for 1-3 projects/year. 1.C.To provide infrastructure support for the Pilot Projects.during the award period._ l.D.To monitor the progress of the Pilot Projects on a quarterly basis and to monitor the overall success of the program by tracking publications and extramural funding obtained on the basis of Pilot Project support.

Public Health Relevance

Annual influenza epidemics are a serious public health problem;influenza pandemics are a major threat. It is important to provide resources such as seed funds for Pilot Projects to support new research ideas or technologies that could be developed to address critical questions in human immunology.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI057229-10
Application #
8508802
Study Section
Special Emphasis Panel (ZAI1-KS-I)
Project Start
2013-04-01
Project End
2014-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
10
Fiscal Year
2013
Total Cost
$131,174
Indirect Cost
$37,174
Name
Stanford University
Department
Type
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
Krishnaswamy, Smita; Spitzer, Matthew H; Mingueneau, Michael et al. (2014) Systems biology. Conditional density-based analysis of T cell signaling in single-cell data. Science 346:1250689
Bendall, Sean C; Davis, Kara L; Amir, El-Ad David et al. (2014) Single-cell trajectory detection uncovers progression and regulatory coordination in human B cell development. Cell 157:714-25
Gaudillière, Brice; Fragiadakis, Gabriela K; Bruggner, Robert V et al. (2014) Clinical recovery from surgery correlates with single-cell immune signatures. Sci Transl Med 6:255ra131
Sen, Adrish; Rott, Lusijah; Phan, Nguyen et al. (2014) Rotavirus NSP1 protein inhibits interferon-mediated STAT1 activation. J Virol 88:41-53
Furman, David; Hejblum, Boris P; Simon, Noah et al. (2014) Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination. Proc Natl Acad Sci U S A 111:869-74
Sen, Nandini; Mukherjee, Gourab; Sen, Adrish et al. (2014) Single-cell mass cytometry analysis of human tonsil T cell remodeling by varicella zoster virus. Cell Rep 8:633-45
Pernas, Lena; Ramirez, Raymund; Holmes, Tyson H et al. (2014) Immune profiling of pregnant Toxoplasma-infected US and Colombia patients reveals surprising impacts of infection on peripheral blood cytokines. J Infect Dis 210:923-31
Bruggner, Robert V; Bodenmiller, Bernd; Dill, David L et al. (2014) Automated identification of stratifying signatures in cellular subpopulations. Proc Natl Acad Sci U S A 111:E2770-7
Chang, Serena; Kohrt, Holbrook; Maecker, Holden T (2014) Monitoring the immune competence of cancer patients to predict outcome. Cancer Immunol Immunother 63:713-9
Birnbaum, Michael E; Mendoza, Juan L; Sethi, Dhruv K et al. (2014) Deconstructing the peptide-MHC specificity of T cell recognition. Cell 157:1073-87

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