The major objectives of the Administrative Core of the Cooperative Center on Human Immunology at the Emory Vaccine Center (CCHI-EVC) are to Institute streamlined processes facilitating productive Interactions among the investigators of the renewal grant application entitled "Vaccine Induced Immunity in the Young and Aged". In order to achieve these objectives and to ensure a seamless operation of the Core, we will establish an Operations Office, which will be responsible for carrying out the following activities/functions at the CCHI-EVC: 1) Provide the Infrastructure for the overall management and co-ordination. 2) Facilitate and promote communication and interaction among the PIs/Investigators (Research Projects, Technology Development Project and Cores) by conducting regular teleconferences/face-to-face meetings, annual meetings, as well as seminars/symposia on human immunology of bio-defense pathogens. 3) Coordinate yearly meetings of the External Scientific Advisory Group and Implement their recommendations. 4) Resolve all or any potential conflicts that might arise within and outside of CCHI-EVC by implementing recommendations of the Conflicts Resolution Group. 5) Provide fiscal/scientific oversight, review and consolidate yearly progress reports sent to the NIH. 6) Protect intellectual property rights of CCHI-EVC investigators and to execute material transfer agreements. 7) Devise a plan for data management/sharing among Investigators In and out of CCHI-EVC. Thus, the Administrative Core Is organized to foster a high degree of synergy and productive Interaction among Investigators for achieving success In the overall objectives of CCHI-EVC.

Public Health Relevance

The Administrative Core is designed to play a central role in the coordination of both scientific and administrative activities among the various Institutions represented at the CCHI-EVC and to promote synergistic interactions.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZAI1-LAR-I (J1))
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Emory University
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Fang, Fengqin; Yu, Mingcan; Cavanagh, Mary M et al. (2016) Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals. Cell Rep 14:1218-31
Ravindran, Rajesh; Loebbermann, Jens; Nakaya, Helder I et al. (2016) The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation. Nature 531:523-7
Chandele, Anmol; Sewatanon, Jaturong; Gunisetty, Sivaram et al. (2016) Characterization of Human CD8 T Cell Responses in Dengue Virus-Infected Patients from India. J Virol 90:11259-11278
Neu, Karlynn E; Henry Dunand, Carole J; Wilson, Patrick C (2016) Heads, stalks and everything else: how can antibodies eradicate influenza as a human disease? Curr Opin Immunol 42:48-55
DiLillo, David J; Palese, Peter; Wilson, Patrick C et al. (2016) Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection. J Clin Invest 126:605-10
Henry Dunand, Carole J; Leon, Paul E; Huang, Min et al. (2016) Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection. Cell Host Microbe 19:800-13
Qi, Qian; Cavanagh, Mary M; Le Saux, Sabine et al. (2016) Diversification of the antigen-specific T cell receptor repertoire after varicella zoster vaccination. Sci Transl Med 8:332ra46
Ho, Irvin Y; Bunker, Jeffrey J; Erickson, Steven A et al. (2016) Refined protocol for generating monoclonal antibodies from single human and murine B cells. J Immunol Methods 438:67-70
Nakaya, Helder I; Clutterbuck, Elizabeth; Kazmin, Dmitri et al. (2016) Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood. Proc Natl Acad Sci U S A 113:1853-8
Burke, Rachel M; Suchdev, Parminder S; Rebolledo, Paulina A et al. (2016) Predictors of Inflammation in a Cohort of Bolivian Infants and Toddlers. Am J Trop Med Hyg 95:954-963

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