The success of the UCLA-CMCR in the last funding period is a reflection of the fact that Core A achieved its goal of maximizing the benefit UCLA can give to the CMCR through the efforts of an integrated executive committee made up of senior investigators, working together with experienced administrators. Core A has established three major levels of organization to ensure effective planning, scientific exchange, oversight, and educational success. These are the Executive Committee, and the outstanding scientists on the Internal and the External Scientific Review Groups (ISAG/ESAG). The Executive Committee of the CMCR is composed of Drs. McBride, SchiestI and Cheng who are all deeply immersed in the scientific fabric of UCLA and play numerous leadership roles locally, nationally and internationally. The UCLA-CMCR is built around extremely strong multidisciplinary Projects and Cores that have grown in size as they incorporated personnel and ideas from Pilot Research Projects the best of what UCLA can offer in science. Dr. Gatti, past member of the Executive Committee, will chair the ISAG and continues to lead Pilot Project Program Core B. This ensures that the ISAG will continue to play a major role in identifying quality personnel and research projects for the future and that ISAG recommendations are fully incorporated into the UCLA-CMCR. The ESAG, which will continue to be Chaired by Dr. Morgan, will continue to guide the Executive Committee by performing quality assurance for all aspects of the Program and making recommendations as to directions in which to proceed. The Core will continue to promote interactions between investigators in full and pilot projects and Cores, in the CMCR network, with CMCR Program leaders, and with industry. This has been very successful in the last period as is seen by the large increase in the number of investigators participating in the UCLA-CMCR regular meetings and symposia organized by this Core, and in participation in CMCR meetings. The Core will ensure Biostatistical support for all investigators. This will be provided by Dr. Sayre, who will be integrated into the Center's activities. Finally, the Core will be responsible for administrative, fiscal, and executive decisions, as well as scientific productivity and contributions to the CMCR Program as a whole.
The UCLA-CMCR Program has, through the efforts of this Core, brought outstanding scientists to address the important issue of how best to mitigate radiafion damage occurring to people as a result of a nuclear accident or terrorist action. The Core also ensures that the Program is fiscally responsible and that the highest ethical and moral standards are maintained.
|Micewicz, Ewa D; Luong, Hai T; Jung, Chun-Ling et al. (2014) Novel dimeric Smac analogs as prospective anticancer agents. Bioorg Med Chem Lett 24:1452-7|
|Damoiseaux, Robert (2014) UCLA's Molecular Screening Shared Resource: enhancing small molecule discovery with functional genomics and new technology. Comb Chem High Throughput Screen 17:356-68|
|Erde, Jonathan; Loo, Rachel R Ogorzalek; Loo, Joseph A (2014) Enhanced FASP (eFASP) to increase proteome coverage and sample recovery for quantitative proteomic experiments. J Proteome Res 13:1885-95|
|Bunimovich, Yuri L; Nair-Gill, Evan; Riedinger, Mireille et al. (2014) Deoxycytidine kinase augments ATM-Mediated DNA repair and contributes to radiation resistance. PLoS One 9:e104125|
|Martin, N T; Nakamura, K; Paila, U et al. (2014) Homozygous mutation of MTPAP causes cellular radiosensitivity and persistent DNA double-strand breaks. Cell Death Dis 5:e1130|
|Hacke, K; Treger, J A; Bogan, B T et al. (2013) Genetic modification of mouse bone marrow by lentiviral vector-mediated delivery of hypoxanthine-Guanine phosphoribosyltransferase short hairpin RNA confers chemoprotection against 6-thioguanine cytotoxicity. Transplant Proc 45:2040-4|
|Martin, Nathan T; Nakamura, Kotoka; Davies, Robert et al. (2013) ATM-dependent MiR-335 targets CtIP and modulates the DNA damage response. PLoS Genet 9:e1003505|
|Xie, Michael W; Gorodetsky, Raphael; Micewicz, Ewa D et al. (2013) Marrow-derived stromal cell delivery on fibrin microbeads can correct radiation-induced wound-healing deficits. J Invest Dermatol 133:553-61|
|Ambrose, Mark; Gatti, Richard A (2013) Pathogenesis of ataxia-telangiectasia: the next generation of ATM functions. Blood 121:4036-45|
|Li, Xinmin; Zhou, Jian; Nahas, Shareef A et al. (2012) Common copy number variations in fifty radiosensitive cell lines. Genomics 99:96-100|
Showing the most recent 10 out of 63 publications