The goal of this Pilot Project Program is to continue to provide funding, access to core facilities, and intellectual support for Pilot Research / Development Projects. In the review procedure, there will be an emphasis on junior investigators and others new to the field of radiation countermeasure development;pilot project collaborations with other members ofthe CMCR network will also be given priority. The broad objective of the program is to provide eariy stage support to foster innovative, exploratory, and developmental R&D projects, which have the potential to lead to practical products in the field of high throughput radiation biodosimetry. To date, the Pilot Program has awarded to 21 pilot projects over the course of this grant. Investigators from 4 departments at Columbia University and 9 other institutions in the USA, Germany, and Australia were awarded pilot projects. Research initiated in these pilot grants has resulted in 6 federal grants/contracts being awarded, 7 patent applications, and 34 peer-reviewed publications (23 published, 5 in press and 6 submitted). Investigators have presented their results at National and International meetings Pilot projects have been and will continue to be solicited and evaluated using a novel two-stage approach, by our Internal Advisory Committee and then by our External Scientific Advisory Group. Progress will continue to be monitored and evaluated on a regular basis.

Public Health Relevance

A large scale radiological event could result in mass casualties from multiple types of radiation exposures, and there is thus a need for rapid, high-throughput biodosimetry to identify those who most require treatment. The Pilot Project Core will support innovative projects with potential to contribute towards high throughput biodosimetry, and also for potentially identifying individuals with particular sensitivities to radiation.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI067773-10
Application #
8705355
Study Section
Special Emphasis Panel (ZAI1-KS-I)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
10
Fiscal Year
2014
Total Cost
$428,402
Indirect Cost
$128,402
Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Sprung, Carl N; Ivashkevich, Alesia; Forrester, Helen B et al. (2015) Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects. Cancer Lett 356:72-81
Shuryak, Igor; Lubin, Jay H; Brenner, David J (2014) Potential for adult-based epidemiological studies to characterize overall cancer risks associated with a lifetime of CT scans. Radiat Res 181:584-91
Turner, Helen C; Sharma, P; Perrier, J R et al. (2014) The RABiT: high-throughput technology for assessing global DSB repair. Radiat Environ Biophys 53:265-72
Repin, Mikhail; Turner, Helen C; Garty, Guy et al. (2014) Next generation platforms for high-throughput biodosimetry. Radiat Prot Dosimetry 159:105-10
Laiakis, Evagelia C; Mak, Tytus D; Anizan, Sebastien et al. (2014) Development of a metabolomic radiation signature in urine from patients undergoing total body irradiation. Radiat Res 181:350-61
Goudarzi, Maryam; Weber, Waylon; Mak, Tytus D et al. (2014) Development of urinary biomarkers for internal exposure by cesium-137 using a metabolomics approach in mice. Radiat Res 181:54-64
Forrester, Helen B; Li, Jason; Leong, Trevor et al. (2014) Identification of a radiation sensitivity gene expression profile in primary fibroblasts derived from patients who developed radiotherapy-induced fibrosis. Radiother Oncol 111:186-93
Forrester, Helen B; Sprung, Carl N (2014) Intragenic controls utilizing radiation-induced alternative transcript regions improves gene expression biodosimetry. Radiat Res 181:314-23
Luo, Xiuquan; Suzuki, Masatoshi; Ghandhi, Shanaz A et al. (2014) ATM regulates insulin-like growth factor 1-secretory clusterin (IGF-1-sCLU) expression that protects cells against senescence. PLoS One 9:e99983
Paul, Sunirmal; Ghandhi, Shanaz A; Weber, Waylon et al. (2014) Gene expression response of mice after a single dose of 137CS as an internal emitter. Radiat Res 182:380-9

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