The goal of this Pilot Project Program is to continue to provide funding, access to core facilities, and intellectual support for Pilot Research / Development Projects. In the review procedure, there will be an emphasis on junior investigators and others new to the field of radiation countermeasure development;pilot project collaborations with other members ofthe CMCR network will also be given priority. The broad objective of the program is to provide eariy stage support to foster innovative, exploratory, and developmental R&D projects, which have the potential to lead to practical products in the field of high throughput radiation biodosimetry. To date, the Pilot Program has awarded to 21 pilot projects over the course of this grant. Investigators from 4 departments at Columbia University and 9 other institutions in the USA, Germany, and Australia were awarded pilot projects. Research initiated in these pilot grants has resulted in 6 federal grants/contracts being awarded, 7 patent applications, and 34 peer-reviewed publications (23 published, 5 in press and 6 submitted). Investigators have presented their results at National and International meetings Pilot projects have been and will continue to be solicited and evaluated using a novel two-stage approach, by our Internal Advisory Committee and then by our External Scientific Advisory Group. Progress will continue to be monitored and evaluated on a regular basis.

Public Health Relevance

A large scale radiological event could result in mass casualties from multiple types of radiation exposures, and there is thus a need for rapid, high-throughput biodosimetry to identify those who most require treatment. The Pilot Project Core will support innovative projects with potential to contribute towards high throughput biodosimetry, and also for potentially identifying individuals with particular sensitivities to radiation.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI067773-10
Application #
8705355
Study Section
Special Emphasis Panel (ZAI1-KS-I)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
10
Fiscal Year
2014
Total Cost
$428,402
Indirect Cost
$128,402
Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Laiakis, Evagelia C; Pannkuk, Evan L; Diaz-Rubio, Maria Elena et al. (2016) Implications of genotypic differences in the generation of a urinary metabolomics radiation signature. Mutat Res 788:41-9
Bertucci, Antonella; Smilenov, Lubomir B; Turner, Helen C et al. (2016) In vitro RABiT measurement of dose rate effects on radiation induction of micronuclei in human peripheral blood lymphocytes. Radiat Environ Biophys 55:53-9
Bian, Dakai; Tsui, Jason C; Repin, Mikhail et al. (2016) Liquid Handling Optimization in High-Throughput Biodosimetry Tool. J Med Device 10:0410071-4100710
Chen, Zhidan; Coy, Stephen L; Pannkuk, Evan L et al. (2016) Rapid and High-Throughput Detection and Quantitation of Radiation Biomarkers in Human and Nonhuman Primates by Differential Mobility Spectrometry-Mass Spectrometry. J Am Soc Mass Spectrom 27:1626-36
Edmondson, David A; Karski, Erin E; Kohlgruber, Ayano et al. (2016) Transcript Analysis for Internal Biodosimetry Using Peripheral Blood from Neuroblastoma Patients Treated with (131)I-mIBG, a Targeted Radionuclide. Radiat Res 186:235-44
Lacombe, Jerome; Phillips, Shanna Leslie; Zenhausern, Frederic (2016) Microfluidics as a new tool in radiation biology. Cancer Lett 371:292-300
Ghandhi, Shanaz A; Smilenov, Lubomir B; Elliston, Carl D et al. (2015) Radiation dose-rate effects on gene expression for human biodosimetry. BMC Med Genomics 8:22
Goldman, Devorah C; Alexeev, Vitali; Lash, Elizabeth et al. (2015) The triterpenoid RTA 408 is a robust mitigator of hematopoietic acute radiation syndrome in mice. Radiat Res 183:338-44
Sprung, Carl N; Ivashkevich, Alesia; Forrester, Helen B et al. (2015) Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects. Cancer Lett 356:72-81
Mak, Tytus D; Tyburski, John B; Krausz, Kristopher W et al. (2015) Exposure to ionizing radiation reveals global dose- and time-dependent changes in the urinary metabolome of rat. Metabolomics 11:1082-1094

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