The Administrative Core A will provide oversight of the entire VCD AADCRC to ensure efficient operations and facilitate scientific collaborations. Dr. Schwartz will direct Core A in collaboration with the other Project/Core Leaders, who together will form the Executive Committee of the VCU AADCRC. An Administrative Assistant will assist the Director. Administrative functions of Core A include the organization and implementation of monthly research meetings of the VCU AADCRC investigators, and of quarterly business meetings of the Executive Committee. Daily operations will be managed by Project and Core Leaders. The Director, with advice from the Executive Committee, will select three new external reviewers on an annual basis (to promote fresh insights), and will also organize the annual visit of these reviewers and the associated VCU AADCRC Program Symposium, which will be held at VCU and will be open to the public and general research and medical communities. The Executive Committee will monitor the performance of Scientific Cores B and C to ensure that the needs of all AADCRC VCU investigators are met. The VCU AADCRC database also will be monitored with the aim of optimizing data sharing among AADCRC investigators during the early phases of research, and with the general scientific community at an appropriate time thereafter. Travel plans to attend the NIH Steering committee meeting and associated scientific conference will be organized through this Administrative Core A. This administrative structure will provide a conducive environment for collaborative interactions and scientific research to flourish.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI077435-05
Application #
8375537
Study Section
Special Emphasis Panel (ZAI1-QV-I)
Project Start
2012-04-01
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
5
Fiscal Year
2012
Total Cost
$76,696
Indirect Cost
$32,819
Name
Virginia Commonwealth University
Department
Type
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298
Oskeritzian, Carole A; Hait, Nitai C; Wedman, Piper et al. (2015) The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell-dependent acute allergic responses. J Allergy Clin Immunol 135:1008-18.e1
Oyeniran, Clement; Sturgill, Jamie L; Hait, Nitai C et al. (2015) Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice. J Allergy Clin Immunol 136:1035-46.e6
Kim, Eugene Y; Sturgill, Jamie L; Hait, Nitai C et al. (2014) Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching. FASEB J 28:4347-58
Morales, Johanna K; Saleem, Sheinei J; Martin, Rebecca K et al. (2014) Myeloid-derived suppressor cells enhance IgE-mediated mast cell responses. J Leukoc Biol 95:643-50
Faber, Travis W; Pullen, Nicholas A; Fernando, Josephine F A et al. (2014) ADAM10 is required for SCF-induced mast cell migration. Cell Immunol 290:80-8
Le, Quang Trong; Lotfi-Emran, Sahar; Min, Hae-Ki et al. (2014) A simple, sensitive and safe method to determine the human α/β-tryptase genotype. PLoS One 9:e114944
Martin, Rebecca K; Saleem, Sheinei J; Folgosa, Lauren et al. (2014) Mast cell histamine promotes the immunoregulatory activity of myeloid-derived suppressor cells. J Leukoc Biol 96:151-9
Lyons, Jonathan J; Sun, Guangping; Stone, Kelly D et al. (2014) Mendelian inheritance of elevated serum tryptase associated with atopy and connective tissue abnormalities. J Allergy Clin Immunol 133:1471-4
Liang, Jie; Nagahashi, Masayuki; Kim, Eugene Y et al. (2013) Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. Cancer Cell 23:107-20
Nagahashi, Masayuki; Kim, Eugene Y; Yamada, Akimitsu et al. (2013) Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network. FASEB J 27:1001-11

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