The Administrative Core (A) proposed will provide administrative support for the four scientific projects and the clinical laboratory core (B) comprising this program entitled """"""""The University of Pittsburgh Medical Center Sexually Transmitted Infections Cooperative Research Center"""""""" (UPMC STI-CRC) and will be directed by Dr. Toni Darville. The administrative core will play an integral role in facilitating the integration of the projects proposed in this cooperative agreement program. In particular, a key attribute of the proposed UPMC STICRC involves the high degree of collaboration between the individual projects and cores that reflects the shared interest of the principal investigators in determining specific host and pathogenic mechanisms that contribute to the development of upper reproductive tract infections due to sexually transmitted organisms and endogenous microbes. The Administrative Core will: (1) Provide administrative oversight for the scientific conduct of each of the projects and cores, ensuring adequate integration and collaboration between the individual projects. (2) Provide fiscal oversight. (3) Interact with NIH representatives to implement strategic planning and ensure that reporting requirements to NIH are met. (4) Coordinate interactions with the biostatistics and data management services of the University of Pittsburgh Clinical and Translational Science Institute (CTSI). (5) Facilitate data sharing and intellectual property management. (6) Provide administrative/secretarial support to the UPMC STI-CRC. The Administrative Core will comprise the Center Director, Co-Center Director, and an administrative assistant.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI084024-04
Application #
8379415
Study Section
Special Emphasis Panel (ZAI1-MMT-M)
Project Start
Project End
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
4
Fiscal Year
2012
Total Cost
$225,377
Indirect Cost
$44,747
Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Russell, Ali N; Zheng, Xiaojing; O'Connell, Catherine M et al. (2016) Analysis of Factors Driving Incident and Ascending Infection and the Role of Serum Antibody in Chlamydia trachomatis Genital Tract Infection. J Infect Dis 213:523-31
Russell, Ali N; Zheng, Xiaojing; O'Connell, Catherine M et al. (2016) Identification of Chlamydia trachomatis Antigens Recognized by T Cells From Highly Exposed Women Who Limit or Resist Genital Tract Infection. J Infect Dis 214:1884-1892
Barral, Romina; Desai, Ruchi; Zheng, Xiaojing et al. (2014) Frequency of Chlamydia trachomatis-specific T cell interferon-γ and interleukin-17 responses in CD4-enriched peripheral blood mononuclear cells of sexually active adolescent females. J Reprod Immunol 103:29-37
Taylor, Brandie D; Darville, Toni; Ferrell, Robert E et al. (2014) Cross-sectional analysis of Toll-like receptor variants and bacterial vaginosis in African-American women with pelvic inflammatory disease. Sex Transm Infect 90:563-6
Darville, Toni; Pelvic Inflammatory Disease Workshop Proceedings Committee (2013) Pelvic inflammatory disease: identifying research gaps--proceedings of a workshop sponsored by Department of Health and Human Services/National Institutes of Health/National Institute of Allergy and Infectious Diseases, November 3-4, 2011. Sex Transm Dis 40:761-7
Darville, Toni (2013) Recognition and treatment of chlamydial infections from birth to adolescence. Adv Exp Med Biol 764:109-22
Frazer, Lauren C; Scurlock, Amy M; Zurenski, Matthew A et al. (2013) IL-23 induces IL-22 and IL-17 production in response to Chlamydia muridarum genital tract infection, but the absence of these cytokines does not influence disease pathogenesis. Am J Reprod Immunol 70:472-84
Vicetti Miguel, Rodolfo D; Harvey, Stephen A K; LaFramboise, William A et al. (2013) Human female genital tract infection by the obligate intracellular bacterium Chlamydia trachomatis elicits robust Type 2 immunity. PLoS One 8:e58565
Taylor, Brandie D; Darville, Toni; Ferrell, Robert E et al. (2013) Racial variation in toll-like receptor variants among women with pelvic inflammatory disease. J Infect Dis 207:940-6
Ahmed, Azad; Earl, Josh; Retchless, Adam et al. (2012) Comparative genomic analyses of 17 clinical isolates of Gardnerella vaginalis provide evidence of multiple genetically isolated clades consistent with subspeciation into genovars. J Bacteriol 194:3922-37

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