In India, the world's largest democracy and second most populous country, malaria remains an enormous public health problem. The National Institute of Malaria Research (NIMR) in New Delhi is the only institute in India dedicated to finding short- and long-term solutions to the problem of malaria through basic, applied, and operational field research. The Center for the Study of Complex Malaria in India (CSCMi) will bring together a group of leading US experts in the fields of malaria parasite research to work in tandem with faculty at the NIMR. Malaria in India is 'complex';two predominant species of parasite infect almost equal numbers of people, and may be present serially or concurrently in one person. Each species also has multiple strains (genotypes) that can serially or concurrently infect. Indian malaria complexity, its variation by location, and its consequences for malaria severity and transmission, are the research focus of the CSCMi, which aims to develop the knowledge, tools, and evidence-based strategies needed to support the intervention and control programs of Indian government organizations, and to build research capacity in India and help train its next generation of malaria and mosquito vector biologists. CSCMi research comprises three Projects: 1) Epidemiology, 2) Transmission, and 3) Pathology and Diagnosis. Project 1 will rely on multiple blood samples from 3000 (1000 x 3) longitudinally-tracked individuals, both symptomatic and asymptomatic for different malarias, recruited at three ecologically and epidemiologically diverse NIMR field sites. It will assess how infection complexity, parasite diversity, and transmission rate impact immunity. Project 2 will investigate ecological and evolutionary determinants of malaria transmission, and the efficacy of novel evolution-proof bio-insecticides for disrupting transmission of simple and complex malaria. Project 3 will deploy next-generation genomics to study multiplicity of infection and the rise of antimalarial drug-resistant clones, and to develop a diagnostic test for drug-resistant parasites. CSCMi projects will be supported by Administrative, Data Management, and Genomics Cores to be located at the NIMR's new facility in Dwarka, New Delhi.

Public Health Relevance

Malaria is a major public health problem in India, the world's largest democracy and its second most populous country. The CSCMi will be a collaborative scientific research institute comprising US and Indian malaria experts and dedicated staff at the National Institute for Malaria Research in Delhi and NIMR field stations, all working towards the goal of enhancing malaria intervention and control programs in India.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI089676-05
Application #
8699667
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Rao, Malla R
Project Start
2010-07-01
Project End
2017-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
New York University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10012
Mohanty, Sanjib; Benjamin, Laura A; Majhi, Megharay et al. (2017) Magnetic Resonance Imaging of Cerebral Malaria Patients Reveals Distinct Pathogenetic Processes in Different Parts of the Brain. mSphere 2:
Waite, Jessica L; Swain, Sunita; Lynch, Penelope A et al. (2017) Increasing the potential for malaria elimination by targeting zoophilic vectors. Sci Rep 7:40551
Thomas, Shalu; Ravishankaran, Sangamithra; Justin, N A Johnson Amala et al. (2017) Resting and feeding preferences of Anopheles stephensi in an urban setting, perennial for malaria. Malar J 16:111
Wassmer, Samuel Crocodile; Grau, Georges Emile Raymond (2017) Severe malaria: what's new on the pathogenesis front? Int J Parasitol 47:145-152
Mooney, Jason Paul; Wassmer, Samuel Crocodile; Hafalla, Julius Clemence (2017) Type I Interferon in Malaria: A Balancing Act. Trends Parasitol 33:257-260
Beck-Johnson, Lindsay M; Nelson, William A; Paaijmans, Krijn P et al. (2017) The importance of temperature fluctuations in understanding mosquito population dynamics and malaria risk. R Soc Open Sci 4:160969
Uplekar, Swapna; Rao, Pavitra Nagesh; Ramanathapuram, Lalitha et al. (2017) Characterizing Antibody Responses to Plasmodium vivax and Plasmodium falciparum Antigens in India Using Genome-Scale Protein Microarrays. PLoS Negl Trop Dis 11:e0005323
Gruszczyk, Jakub; Lim, Nicholas T Y; Arnott, Alicia et al. (2016) Structurally conserved erythrocyte-binding domain in Plasmodium provides a versatile scaffold for alternate receptor engagement. Proc Natl Acad Sci U S A 113:E191-200
Thomas, Shalu; Ravishankaran, Sangamithra; Justin, Johnson A et al. (2016) Overhead tank is the potential breeding habitat of Anopheles stephensi in an urban transmission setting of Chennai, India. Malar J 15:274
Gallego-Delgado, Julio; Basu-Roy, Upal; Ty, Maureen et al. (2016) Angiotensin receptors and ?-catenin regulate brain endothelial integrity in malaria. J Clin Invest 126:4016-4029

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