The purpose of the administrative core is to ensure the effective overall administration and coordination of the Center. To accomplish those goals, the Administrative Core (Core A) has been organized in four specific aims: 1] Track scientific progress and accomplishments for each of the individual projects and cores, 2] Identify and ensure the coordination of related studies at different field sites, 3] Ensure compliance with IRBs and other regulatory authorities for studies of human subjects, and 4] Develop administrative guidelines (including subcontracts) to define the responsibilities of investigators, and to ensure the responsible management of funds. The first objective is to track progress on the Milestones and Timelines developed by the individual projects and cores. This will be accomplished using a combination of electronic (WEB-based) communications, conference calls, site visits, face-to-face meetings, regional scientific interchanges and short-term training. The rationale forthe second objective is that the identification of common (shared) successes and obstacles among field sites is an important justification for this RFA to develop International Centers of Excellence for Malaria Research. The rationale for the third objective is that the enormous number of guidelines and authorities which regulate the performance human studies is a potential obstacle to the success of these studies. This issue will be addressed by hiring a Compliance Officer within the Administrative Core and by providing similar staff support at each of the participating sites. The rationale for the fourth objective is that the management of funds is more difficult with international projects. That challenge will be addressed by providing support to ensure the timely transfers of funds among institutions, by electronic reporting of expenditures, and by drawing on templates that have been used successfully in the past for subcontracts. The long-term objectives of the Administrative Core are to: 1] develop expertise in research administration within West and Central Africa, 2] provide regional leadership on administrative issues related to health research and 3] provide a foundation to move from capacity building (training of individuals) to the development of research institutions and networks.

Public Health Relevance

This proposal is directly relevant to public health because malaria continues to take an enormous toll across the globe, particularly among children less than 5 years of age in sub-Saharan Africa. Its goals are to examine the epidemiology and transmission of malaria at four field sites and relate those successes and failures to regional and global progress and problems in the effort to control and eliminate malaria.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZAI1-AWA-M)
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Tulane University
New Orleans
United States
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Mbaye, Aminata; Gaye, Amy; Dieye, Baba et al. (2017) Ex vivo susceptibility and genotyping of Plasmodium falciparum isolates from Pikine, Senegal. Malar J 16:250
Koita, Ousmane A; Sangaré, Lansana; Miller, Haiyan D et al. (2017) AQ-13, an investigational antimalarial, versus artemether plus lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria: a randomised, phase 2, non-inferiority clinical trial. Lancet Infect Dis 17:1266-1275
Ndiaye, Yaye Dié; Diédhiou, Cyrille K; Bei, Amy K et al. (2017) High resolution melting: a useful field-deployable method to measure dhfr and dhps drug resistance in both highly and lowly endemic Plasmodium populations. Malar J 16:153
Talundzic, Eldin; Ndiaye, Yaye D; Deme, Awa B et al. (2017) Molecular Epidemiology of Plasmodium falciparum kelch13 Mutations in Senegal Determined by Using Targeted Amplicon Deep Sequencing. Antimicrob Agents Chemother 61:
Koita, Ousmane A; Murphy, Robert L; Fongoro, Saharé et al. (2016) Clinical Research and the Training of Host Country Investigators: Essential Health Priorities for Disease-Endemic Regions. Am J Trop Med Hyg 94:253-7
Dieye, Baba; Affara, Muna; Sangare, Lassana et al. (2016) West Africa International Centers of Excellence for Malaria Research: Drug Resistance Patterns to Artemether-Lumefantrine in Senegal, Mali, and The Gambia. Am J Trop Med Hyg 95:1054-1060
Mbaye, Aminata; Dieye, Baba; Ndiaye, Yaye D et al. (2016) Selection of N86F184D1246 haplotype of Pfmrd1 gene by artemether-lumefantrine drug pressure on Plasmodium falciparum populations in Senegal. Malar J 15:433
Carlton, Jane M; Volkman, Sarah K; Uplekar, Swapna et al. (2015) Population Genetics, Evolutionary Genomics, and Genome-Wide Studies of Malaria: A View Across the International Centers of Excellence for Malaria Research. Am J Trop Med Hyg 93:87-98
Cui, Liwang; Mharakurwa, Sungano; Ndiaye, Daouda et al. (2015) Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network. Am J Trop Med Hyg 93:57-68
Moss, William J; Dorsey, Grant; Mueller, Ivo et al. (2015) Malaria Epidemiology and Control Within the International Centers of Excellence for Malaria Research. Am J Trop Med Hyg 93:5-15

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