The Clinical/Statistical Core will provide the research projects with appropriate human clinical specimens and data from studies of vaccination or infection for influenza, pneumococcus, and varicella zoster virus. The Clinical/Statistical Core has three units that will support the research projects: the Hope Clinic Unit located at Emory U.;the Denver Clinic Unit located at the U of Colorado;and the Statistical Unit located at Emory U.
The specific aims of the Clinical/Statistical Core are:
Specific aim 1) To provide clinical study expertise and capacity to ensure the success of the U19 scientific agenda.
Specific aim 2) To provide statistical and data management expertise that ensures the success of the U19 scientific agenda.
Specific aim 3) To perform clinical studies with inactivated trivalent influenza vaccine (TIV) that will provide the clinical specimens and data necessary to accomplish the scientific aims of the research projects.
Specific aim 4) To perform clinical studies with 23-valent pneumococcal polysaccharide vaccine (PPV23) and in subjects with pneumococcal infections that will provide the clinical specimens and data necessary to accomplish the scientific aims of the projects.
Specific aim 5) To perform clinical studies with zoster vaccine (ZV) and with herpes zoster (HZ) patients that will provide the clinical specimens and data necessary to accomplish the scientific aims of projects 1 and 2.

Public Health Relevance

;Our recent work with the yellow fever vaccine demonstrates that systems biology approaches provide a new and unbiased way to protje the immune response to vaccination in humans, and discover molecular signatures that can predict vaccine induced immunity. The overarching goal of the present U19 application is to determine whether such an approach is generally applicable to different types of vaccines in the young and elderiy populations. This core will support this endeavor.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
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Emory University
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Suthar, Mehul S; Pulendran, Bali (2014) Systems analysis of West Nile virus infection. Curr Opin Virol 6:70-5
Pulendran, Bali (2014) Systems vaccinology: probing humanity's diverse immune systems with vaccines. Proc Natl Acad Sci U S A 111:12300-6
Janssens, Sophie; Pulendran, Bali; Lambrecht, Bart N (2014) Emerging functions of the unfolded protein response in immunity. Nat Immunol 15:910-9
Tan, Yan; Tamayo, Pablo; Nakaya, Helder et al. (2014) Gene signatures related to B-cell proliferation predict influenza vaccine-induced antibody response. Eur J Immunol 44:285-95
Kwissa, Marcin; Nakaya, Helder I; Onlamoon, Nattawat et al. (2014) Dengue virus infection induces expansion of a CD14(+)CD16(+) monocyte population that stimulates plasmablast differentiation. Cell Host Microbe 16:115-27
Chiu, Christopher; McCausland, Megan; Sidney, John et al. (2014) Broadly reactive human CD8 T cells that recognize an epitope conserved between VZV, HSV and EBV. PLoS Pathog 10:e1004008
Cortese, Mario; Sinclair, Charles; Pulendran, Bali (2014) Translating glycolytic metabolism to innate immunity in dendritic cells. Cell Metab 19:737-9
Oh, Jason Z; Ravindran, Rajesh; Chassaing, Benoit et al. (2014) TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination. Immunity 41:478-92
Yu, Tianwei; Jones, Dean P (2014) Improving peak detection in high-resolution LC/MS metabolomics data using preexisting knowledge and machine learning approach. Bioinformatics 30:2941-8
Ravindran, Rajesh; Khan, Nooruddin; Nakaya, Helder I et al. (2014) Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation. Science 343:313-7

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