The Clinical/Statistical Core will provide the research projects with appropriate human clinical specimens and data from studies of vaccination or infection for influenza, pneumococcus, and varicella zoster virus. The Clinical/Statistical Core has three units that will support the research projects: the Hope Clinic Unit located at Emory U.;the Denver Clinic Unit located at the U of Colorado;and the Statistical Unit located at Emory U.
The specific aims of the Clinical/Statistical Core are:
Specific aim 1) To provide clinical study expertise and capacity to ensure the success of the U19 scientific agenda.
Specific aim 2) To provide statistical and data management expertise that ensures the success of the U19 scientific agenda.
Specific aim 3) To perform clinical studies with inactivated trivalent influenza vaccine (TIV) that will provide the clinical specimens and data necessary to accomplish the scientific aims of the research projects.
Specific aim 4) To perform clinical studies with 23-valent pneumococcal polysaccharide vaccine (PPV23) and in subjects with pneumococcal infections that will provide the clinical specimens and data necessary to accomplish the scientific aims of the projects.
Specific aim 5) To perform clinical studies with zoster vaccine (ZV) and with herpes zoster (HZ) patients that will provide the clinical specimens and data necessary to accomplish the scientific aims of projects 1 and 2.
;Our recent work with the yellow fever vaccine demonstrates that systems biology approaches provide a new and unbiased way to protje the immune response to vaccination in humans, and discover molecular signatures that can predict vaccine induced immunity. The overarching goal of the present U19 application is to determine whether such an approach is generally applicable to different types of vaccines in the young and elderiy populations. This core will support this endeavor.
|Ho, Irvin Y; Bunker, Jeffrey J; Erickson, Steven A et al. (2016) Refined protocol for generating monoclonal antibodies from single human and murine B cells. J Immunol Methods 438:67-70|
|Nakaya, Helder I; Clutterbuck, Elizabeth; Kazmin, Dmitri et al. (2016) Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood. Proc Natl Acad Sci U S A 113:1853-8|
|Quicke, Kendra M; Bowen, James R; Johnson, Erica L et al. (2016) Zika Virus Infects Human Placental Macrophages. Cell Host Microbe 20:83-90|
|Godec, Jernej; Tan, Yan; Liberzon, Arthur et al. (2016) Compendium of Immune Signatures Identifies Conserved and Species-Specific Biology in Response to Inflammation. Immunity 44:194-206|
|Li, Shuzhao; Todor, Andrei; Luo, Ruiyan (2016) Blood transcriptomics and metabolomics for personalized medicine. Comput Struct Biotechnol J 14:1-7|
|Ravindran, Rajesh; Loebbermann, Jens; Nakaya, Helder I et al. (2016) The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation. Nature 531:523-7|
|Peng, Hesen; Ma, Junjie; Bai, Yun et al. (2015) MeDiA: Mean Distance Association and Its Applications in Nonlinear Gene Set Analysis. PLoS One 10:e0124620|
|Wang, Kai; Zhao, Qing; Lu, Jianwei et al. (2015) K-Profiles: A Nonlinear Clustering Method for Pattern Detection in High Dimensional Data. Biomed Res Int 2015:918954|
|Cobey, Sarah; Wilson, Patrick; Matsen 4th, Frederick A (2015) The evolution within us. Philos Trans R Soc Lond B Biol Sci 370:|
|Pulendran, Bali; Maddur, Mohan S (2015) Innate immune sensing and response to influenza. Curr Top Microbiol Immunol 386:23-71|
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