The goal of this core is to serve Projects 1 and 2, by identifying HLA class I and class II epitopes derived from VZV, as a necessary prelude to the analyses of the dynamics of the epitope-specific T cell responses to vaccination with the zoster vaccine (Project 2). This data generated on the epitope specific T cell responses will be critical in evaluating the innate signatures that correlate with, and predict, the magnitude of the epitope specific T cell responses in Project 1. A key question that will be facilitated by the information generated in this core, is whether early innate signatures are capable of predicting the
The goal of this core is to identify the epitopes recognized by antigen-specific T cells that respond to zoster vaccine or infection. This will be a prelude to the analysis of epitope specific T cell responses to vaccination, and facilitate the identification of innate signatures that predict the breadth of the T cell response.
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