The Administrative Core will facilitate and coordinate communications between the members of the Consortium themselves and between them and the 4 members of the Scientific Advisory Board (SAB), all of whom will be Consultants to the Consortium. The major thrust of the proposals made in this application is to investigate and hopefully resolve the problems associated with coagulation dysregulation following organ xenotransplantation in pig-to-primate models. Frequent communication, most likely in the form of conference calls, is likely to be required between members ofthe Consortium and Consultants, all of whom are experts in the field of xenotransplantation and/or coagulation. The Core will help with travel arrangements and hotel accommodation for Consultants visiting Pittsburgh for the annual workshops at which the results of the Consortium's efforts will be discussed and plans made for the future 12-month period. The Core will also arrange travel and hotels for the members of the Consortium who will be participating in the annual meeting with other scientists funded through this RFA. The immunologic and coagulation assays to be used in the studies in Projects 1 and 2 will, as far as possible, be standardized between the two centers, and this will require exchange of samples, tissues, and reagents. This will be organized and coordinated through the Administrative Core. Data from the various experiments and assays will be collected and collated in the Administrative Core. The Core will also be responsible for assisting with the preparation of manuscripts reporting the scientific work of the consortium to be submitted for publication. The Core will do what it can to ensure timely reporting in peer-reviewed journals ofthe results obtained by the Consortium. It is the Consortium's plan to invite other scientists who are working in this field to the annual workshops that will take place in Pittsburgh, even if those scientists are neither Consultants to the Consortium nor funded by the RFA (although these scientists will have to fund their own travel expenses). The members of the Consortium believe that it is only through full collaboration and exchange of ideas and information that the problems of xenotransplantation will be resolved in a timely manner. The Administrative Core will provide assistance to visiting scientists with regard to reserving hotel accommodation, etc.

Public Health Relevance

This U19 will require significant coordination between the various groups participating in these proposed studies, and it will be greatly advantageous if the PD has administrative assistance to enable him to provide the coordination required. The overall results of the proposed studies are likely to be considerably more informative if the studies have been planned and performed in a coordinated fashion. The studies have the realistic potential to advance xenotransplantation towards clinical trials.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI090959-04
Application #
8514499
Study Section
Special Emphasis Panel (ZAI1-JBS-I)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
4
Fiscal Year
2013
Total Cost
$42,270
Indirect Cost
$4,180
Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Buhler, L; Illigens, B M-W; Nadazdin, O et al. (2016) Persistence of Indirect but Not Direct T Cell Xenoresponses in Baboon Recipients of Pig Cell and Organ Transplants. Am J Transplant 16:1917-22
Iwase, Hayato; Ekser, Burcin; Hara, Hidetaka et al. (2016) Thyroid hormone: relevance to xenotransplantation. Xenotransplantation 23:293-9
Cooper, David K C; Matsumoto, Shinichi; Abalovich, Adrian et al. (2016) Progress in Clinical Encapsulated Islet Xenotransplantation. Transplantation 100:2301-2308
Murthy, Raghav; Bajona, Pietro; Bhama, Jay K et al. (2016) Heart Xenotransplantation: Historical Background, Experimental Progress, and Clinical Prospects. Ann Thorac Surg 101:1605-13
Wijkstrom, Martin; Iwase, Hayato; Paris, Wayne et al. (2016) Renal xenotransplantation: experimental progress and clinical prospects. Kidney Int :
Lee, Whayoung; Hara, Hidetaka; Ezzelarab, Mohamed B et al. (2016) Initial in vitro studies on tissues and cells from GTKO/CD46/NeuGcKO pigs. Xenotransplantation 23:137-50
Cooper, David K C (2016) Modifying the sugar icing on the transplantation cake. Glycobiology 26:571-81
Cooper, David K C; Wijkstrom, Martin; Hariharan, Sundaram et al. (2016) Selection of Patients for Initial Clinical Trials of Solid Organ Xenotransplantation. Transplantation :
Cooper, David K C; Ekser, Burcin; Ramsoondar, Jagdeece et al. (2016) The role of genetically engineered pigs in xenotransplantation research. J Pathol 238:288-99
Cooper, David K C; Dou, Ke-Feng; Tao, Kai-Shan et al. (2016) Pig Liver Xenotransplantation: A Review of Progress Toward the Clinic. Transplantation 100:2039-47

Showing the most recent 10 out of 82 publications