This core provides input from what is generally agreed to be the leading EPR instrumental development site in the world, the National Biomedical EPR Center at the Medical College of Wisconsin (MCW). The role of this core will be to provide leadership in the development of specific aspects of the technology needed to accomplish the goals of the CMCR. These developments will be carried out in collaboration with the projects and with the instrumental Core at Dartmouth, to facilitate the development of the best possible o prototype instruments for EPR dosimetry. The contributions ofthe core at MCW are described in four specific aims.
Specific Aim 1 (50% of effort) is the Development of resonators for measurements at X-Band in vivo for nails and teeth;this will be the most extensive project and will focus on exploiting the breakthrough achieved in initial collaborative studies where for the first time, resonators that operate at the very sensitive X-Band frequency were successfully used to make measurements in vivo. This development is at the heart of project 3. During the course of the grant this core will attempt to make analogous resonators that can be used for in vivo tooth dosimetry, which could dramatically improve the already impressive sensitivity of this approach (Project 1).
Specific Aim 2 (25% of effort) - Development of instrumentation to support measurements at X-Band, will especially focus on development of specifically designed microwave bridges that will facilitate both Projects 2 &3. These developments will be carried out in collaboration with a longstanding collaborative partner of both Dr. Hyde and Dr. Swartz, Dr. Froncisz of the Jagiellonian University in Krakow (Dr. Froncisz's support will come via a purchase agreement.
Specific Aim 3 (20% of effort) - Improvements in resonators and bridges for measurements at L-Band. This core will similarly work with Dartmouth and Krakow in the development of improved L-Band bridges, in support of Project 1. It also will facilitate resonator development in project 1 by use of the very sophisticated modeling techniques that are highly developed at MCW, which enable different configurations of resonators to e=be rigorously evaluated so that construction can be focused on designs that are likely to be successful Specific Aim 4 -(5 % of effort) support of multifrequency studies will available an exceptional set of EPR spectrometers that can be of value to all three projects in helping to elucidate the characteristics of potentially overlapping components of EPR spectra.

Public Health Relevance

The instruments to be developed in this core will provide unique and valuable additions to the response capabilities of the medical response to an incident in which large numbers of individuals have potentially been exposed to significant amounts of ionizing radiation, enabling scarce resources to be employed more effectively and reducing the level of anxiety in the population.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI091173-05
Application #
8706007
Study Section
Special Emphasis Panel (ZAI1-KS-I)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
5
Fiscal Year
2014
Total Cost
$391,282
Indirect Cost
$113,333
Name
Dartmouth College
Department
Type
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Rogan, Peter K; Li, Yanxin; Wickramasinghe, Asanka et al. (2014) Automating dicentric chromosome detection from cytogenetic biodosimetry data. Radiat Prot Dosimetry 159:95-104
Sidabras, Jason W; Varanasi, Shiv K; Mett, Richard R et al. (2014) A microwave resonator for limiting depth sensitivity for electron paramagnetic resonance spectroscopy of surfaces. Rev Sci Instrum 85:104707
Swartz, Harold M; Flood, Ann Barry; Williams, Benjamin B et al. (2014) Comparison of the needs for biodosimetry for large-scale radiation events for military versus civilian populations. Health Phys 106:755-63
Williams, Benjamin B; Flood, Ann Barry; Salikhov, Ildar et al. (2014) In vivo EPR tooth dosimetry for triage after a radiation event involving large populations. Radiat Environ Biophys 53:335-46
Ivannikov, Alexander I; Skvortsov, Valeri G; Stepanenko, Valeri F et al. (2014) Comparative analysis between radiation doses obtained by EPR dosimetry using tooth enamel and established analytical methods for the population of radioactively contaminated territories. Radiat Prot Dosimetry 159:125-9
Junwang, Guo; Qingquan, Yuan; Jianbo, Cong et al. (2014) New developed cylindrical TM010 mode EPR cavity for X-band in vivo tooth dosimetry. PLoS One 9:e106587
Flood, Ann Barry; Boyle, Holly K; Du, Gaixin et al. (2014) Advances in a framework to compare bio-dosimetry methods for triage in large-scale radiation events. Radiat Prot Dosimetry 159:77-86
Swartz, Harold M; Williams, Benjamin B; Zaki, Bassem I et al. (2014) Clinical EPR: unique opportunities and some challenges. Acad Radiol 21:197-206
He, Xiaoming; Swarts, Steven G; Demidenko, Eugene et al. (2014) Development and validation of an ex vivo electron paramagnetic resonance fingernail biodosimetric method. Radiat Prot Dosimetry 159:172-81
Swartz, Harold M; Williams, Benjamin B; Flood, Ann Barry (2014) Overview of the principles and practice of biodosimetry. Radiat Environ Biophys 53:221-32

Showing the most recent 10 out of 18 publications