; The overall goal of this core is to centralize data management and analysis services, and thus assure that information produced in the research projects is made available to the scientific community. We will specifically enable assembly of integrated datasets and comparison of results across projects. A secondary goal is to centralize bioinformatics expertise for sequencing analysis. Core C aims to provide and manage a database of blood samples (Aim 1) and provide a central database to characterize and track the enrolled donors and collected samples that will be utilized by all projects. The database will be web-accessible and provide a consistent basis upon which to select samples and interpret results. The database will store general information on the enrolled donors and time dependent clinical information associated with each blood donation, such as presence of symptoms or state of SIT. Laboratory information such as HLA typing data and specific donor &tetramer reactivities will also be stored. Second, we will provide bioinformatic and statistical support to all projects (Aim 2). We will identify the immune response signatures associated with seasonal changes and different disease states (Project 1), and with SIT (Project 2), and the molecular signature associated with asthma (Project 3). Finally, we will assemble, integrate, and submit experimental data to public repositories (Aim3). The research projects in this application will generate large amounts of unique data that will be useful to the scientific community at large. We therefore aim to share our data widely by making them publically available in appropriate repositories.

Public Health Relevance

The data management and analysis services provided by Core C will assure that the Information gained from the research in each project is made accessible and will be comparable across all projects. The high throughput sequencing data analysis services will make specialist bioinformatics expertise available for two of the research projects.

National Institute of Health (NIH)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZAI1)
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La Jolla Institute
La Jolla
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Seumois, Grégory; Chavez, Lukas; Gerasimova, Anna et al. (2014) Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility. Nat Immunol 15:777-88
Schulten, Véronique; Peters, Bjoern; Sette, Alessandro (2014) New strategies for allergen T cell epitope identification: going beyond IgE. Int Arch Allergy Immunol 165:75-82
Arlehamn, Cecilia Lindestam; Seumois, Gregory; Gerasimova, Anna et al. (2014) Transcriptional profile of tuberculosis antigen-specific T cells reveals novel multifunctional features. J Immunol 193:2931-40
Huang, Yun; Chavez, Lukas; Chang, Xing et al. (2014) Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells. Proc Natl Acad Sci U S A 111:1361-6
Schulten, Véronique; Tripple, Victoria; Sidney, John et al. (2014) Association between specific timothy grass antigens and changes in TH1- and TH2-cell responses following specific immunotherapy. J Allergy Clin Immunol 134:1076-83
Gerasimova, Anna; Chavez, Lukas; Li, Bin et al. (2013) Predicting cell types and genetic variations contributing to disease by combining GWAS and epigenetic data. PLoS One 8:e54359
Vaughan, Kerrie; Peters, Bjoern; Larche, Mark et al. (2013) Strategies to query and display allergy-derived epitope data from the immune epitope database. Int Arch Allergy Immunol 160:334-45
McKinney, Denise M; Southwood, Scott; Hinz, Denise et al. (2013) A strategy to determine HLA class II restriction broadly covering the DR, DP, and DQ allelic variants most commonly expressed in the general population. Immunogenetics 65:357-70
Schulten, Veronique; Oseroff, Carla; Alam, Rafeul et al. (2013) The identification of potentially pathogenic and therapeutic epitopes from common human allergens. Ann Allergy Asthma Immunol 110:7-10