Abstract

Innate immune responses permit strong resistance to infection during the hours and days that follow inoculation of microbes. The innate immune system is """"""""hard wired"""""""" in the sense that it depends upon germline-encoded receptors to recognize microbes, and signal transduction pathways to elicit the genetic and biochemical responses that restrict infection. Within our species, inter-individual differences in susceptibility to infection likely reflect differences in innate immune performance, based on differences in genetic mal

Public Health Relevance

When an infection occurs, the innate immune system normally contains it long enough for antibodies and T cells to deal with it definitively. Sometimes innate immunity may even sterilize an infection completely. Hundreds of genes encode proteins that make up our innate immune system, and in identifying all essential components of this system, we may hope to understand what occasionally goes wrong with it: why some people are more prone to infection than others. We may also be able to fashion more effective vaccines. This project is dedicated to the identification of new components of the innate immune system.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI100627-02
Application #
8523783
Study Section
Special Emphasis Panel (ZAI1-QV-I)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
2
Fiscal Year
2013
Total Cost
$787,767
Indirect Cost
$44,430

  Institution

Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Anchang, Benedict; Davis, Kara L; Fienberg, Harris G et al. (2018) DRUG-NEM: Optimizing drug combinations using single-cell perturbation response to account for intratumoral heterogeneity. Proc Natl Acad Sci U S A 115:E4294-E4303
Good, Zinaida; Sarno, Jolanda; Jager, Astraea et al. (2018) Single-cell developmental classification of B cell precursor acute lymphoblastic leukemia at diagnosis reveals predictors of relapse. Nat Med 24:474-483
McAlpine, William; Sun, Lei; Wang, Kuan-Wen et al. (2018) Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function. Proc Natl Acad Sci U S A 115:E11523-E11531
Morin, Matthew D; Wang, Ying; Jones, Brian T et al. (2018) Diprovocims: A New and Exceptionally Potent Class of Toll-like Receptor Agonists. J Am Chem Soc 140:14440-14454
Johnson, Jarrod S; Lucas, Sasha Y; Amon, Lynn M et al. (2018) Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection. Cell Host Microbe 23:366-381.e9
Goltsev, Yury; Samusik, Nikolay; Kennedy-Darling, Julia et al. (2018) Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging. Cell 174:968-981.e15
Wagle, Mayura V; Marchingo, Julia M; Howitt, Jason et al. (2018) The Ubiquitin Ligase Adaptor NDFIP1 Selectively Enforces a CD8+ T Cell Tolerance Checkpoint to High-Dose Antigen. Cell Rep 24:577-584
Wang, Tao; Bu, Chun Hui; Hildebrand, Sara et al. (2018) Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database. Nat Commun 9:441
Jensen, Helle; Chen, Shih-Yu; Folkersen, Lasse et al. (2017) EBI3 regulates the NK cell response to mouse cytomegalovirus infection. Proc Natl Acad Sci U S A 114:1625-1630
McNamara, H A; Cai, Y; Wagle, M V et al. (2017) Up-regulation of LFA-1 allows liver-resident memory T cells to patrol and remain in the hepatic sinusoids. Sci Immunol 2:

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