Innate immune responses permit strong resistance to infection during the hours and days that follow inoculation of microbes. The innate immune system is """"""""hard wired"""""""" in the sense that it depends upon germline-encoded receptors to recognize microbes, and signal transduction pathways to elicit the genetic and biochemical responses that restrict infection. Within our species, inter-individual differences in susceptibility to infection likely reflect differences in innate immune performance, based on differences in genetic mal

Public Health Relevance

When an infection occurs, the innate immune system normally contains it long enough for antibodies and T cells to deal with it definitively. Sometimes innate immunity may even sterilize an infection completely. Hundreds of genes encode proteins that make up our innate immune system, and in identifying all essential components of this system, we may hope to understand what occasionally goes wrong with it: why some people are more prone to infection than others. We may also be able to fashion more effective vaccines. This project is dedicated to the identification of new components of the innate immune system.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI100627-02
Application #
8523783
Study Section
Special Emphasis Panel (ZAI1-QV-I)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
2
Fiscal Year
2013
Total Cost
$787,767
Indirect Cost
$44,430
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
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