The Administrative Core will develop and implement a management plan to ensure the success of the U19 program. This Core will continuously monitor the scientific progress of each component of the program. The Core will facilitate the seamless integration of the members of the consortium. The Core will also facilitate communications with the NIH and with the larger research community. The Core will manage financial resources, ensure that intellectual property issues are respected, and initiate all external collaborations. The educational component of the Core will ensure that the advances made in the program will catalyze innovation in the larger scientific community. Specifically, the Core will offer Phospho-Flow/CyTOF and Systems Immunology courses that will provide the external research community with enhanced hands-on experience and knowledge of systems biology approaches and their applications to the study the immune system.

Public Health Relevance

The Administrative Core will manage the scientific interactions and financial resources of the project and will conduct training course to disseminate methods and techniques developed in this program to other scientists.

Agency
National Institute of Health (NIH)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI100627-03
Application #
8717578
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Bendall, Sean C; Davis, Kara L; Amir, El-Ad David et al. (2014) Single-cell trajectory detection uncovers progression and regulatory coordination in human B cell development. Cell 157:714-25
Zak, Daniel E; Tam, Vincent C; Aderem, Alan (2014) Systems-level analysis of innate immunity. Annu Rev Immunol 32:547-77
Gaudillière, Brice; Fragiadakis, Gabriela K; Bruggner, Robert V et al. (2014) Clinical recovery from surgery correlates with single-cell immune signatures. Sci Transl Med 6:255ra131
Knijnenburg, Theo A; Ramsey, Stephen A; Berman, Benjamin P et al. (2014) Multiscale representation of genomic signals. Nat Methods 11:689-94
Gold, Elizabeth S; Diercks, Alan H; Podolsky, Irina et al. (2014) 25-Hydroxycholesterol acts as an amplifier of inflammatory signaling. Proc Natl Acad Sci U S A 111:10666-71
Yang, Yong; Kulka, Kathleen; Montelaro, Ronald C et al. (2014) A hydrolase of trehalose dimycolate induces nutrient influx and stress sensitivity to balance intracellular growth of Mycobacterium tuberculosis. Cell Host Microbe 15:153-63
Altin, John A; Daley, Stephen R; Howitt, Jason et al. (2014) Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells. Proc Natl Acad Sci U S A 111:2067-74
Zeng, Ming; Hu, Zeping; Shi, Xiaolei et al. (2014) MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses. Science 346:1486-92
Angelo, Michael; Bendall, Sean C; Finck, Rachel et al. (2014) Multiplexed ion beam imaging of human breast tumors. Nat Med 20:436-42
Wang, James Q; Jeelall, Yogesh S; Beutler, Bruce et al. (2014) Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance. J Exp Med 211:413-26

Showing the most recent 10 out of 23 publications