In this study, we aim to functionally interrogate host-pathogen relationships in human influenza viruses. The Proteomics Core will employ a systematic affinity tag/purification-mass spectrometry approach to identify the viral-host protein complexes. The data generated using these initial, unbiased approaches will fuel more targeted, hypothesis-driven research in the subsequent projects. In tandem with this work and with more targeted downstream work, we will be closely monitoring for links to host factors involved in quality control processes, including chaperone function, protein ubiquitination, and protein degradation, which will link this work to the collaborations with Adolfa Garcia-Sastre, Sumit Chanda, and John Young.
Human influenza viruses infect millions of people worldwide each year, resulting in a wide range of clinical outcomes. To gain insight into the pathogenesis of these viruses, we aim to analyze the functional, genetic and biochemical relationships between several members of this class of virus and host cells, which will reveal key human pathways that are being hijacked during infection. This information can ultimately be used to generate novel anti-viral drugs and vaccines.
| Zhao, Nan; Sebastiano, Vittorio; Moshkina, Natasha et al. (2018) Influenza virus infection causes global RNAPII termination defects. Nat Struct Mol Biol 25:885-893 |
| White, Kris M; Abreu Jr, Pablo; Wang, Hui et al. (2018) Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein. ACS Infect Dis 4:146-157 |
| Dornfeld, Dominik; Dudek, Alexandra H; Vausselin, Thibaut et al. (2018) Author Correction: SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses. Sci Rep 8:7782 |
| Zhang, Liang; Wang, Juan; Muñoz-Moreno, Raquel et al. (2018) Influenza Virus NS1 Protein RNA-Interactome Reveals Intron Targeting. J Virol : |
| Hancock, Aidan S; Stairiker, Christopher J; Boesteanu, Alina C et al. (2018) Transcriptome Analysis of Infected and Bystander Type 2 Alveolar Epithelial Cells during Influenza A Virus Infection Reveals In Vivo Wnt Pathway Downregulation. J Virol 92: |
| Dornfeld, Dominik; Dudek, Alexandra H; Vausselin, Thibaut et al. (2018) SMARCA2-regulated host cell factors are required for MxA restriction of influenza A viruses. Sci Rep 8:2092 |
| Heinz, Sven; Texari, Lorane; Hayes, Michael G B et al. (2018) Transcription Elongation Can Affect Genome 3D Structure. Cell 174:1522-1536.e22 |
| Pohl, Marie O; von Recum-Knepper, Jessica; Rodriguez-Frandsen, Ariel et al. (2017) Identification of Polo-like kinases as potential novel drug targets for influenza A virus. Sci Rep 7:8629 |
| Martín-Vicente, María; Medrano, Luz M; Resino, Salvador et al. (2017) TRIM25 in the Regulation of the Antiviral Innate Immunity. Front Immunol 8:1187 |
| García-Sastre, Adolfo (2017) Ten Strategies of Interferon Evasion by Viruses. Cell Host Microbe 22:176-184 |
Showing the most recent 10 out of 39 publications
