The Administrative Core is responsible for the overall management and coordination of the Center of Excellence for Translational Research (CETR) for """"""""Advancement of Treatments for Ebola and Marburg Virus Infections"""""""". It provides governance, financial oversight, and operational management functions to facilitate the execution of the overall research plan, thereby enabling the CETR to fulfill its mission to develop post exposure treatments for Ebola and Marburg hemorrhagic fever. The Administrative Core will provide an organizational and programmatic structure to promote research productivity and synergy through scientific interactions. The Core will provide oversight in setting CETR priorities, including decision-making processes involving the continual evaluation of research and product development. Core personnel will ensure that the CETR is compliant with issues involving the use of vertebrate animals and human subjects, and ensure that regulatory expertise is available for associated translational activities. Management activities are carried out with the advice of the Scientific Advisory Committee in close collaboration with NIAID's biodefense program administrators. Teleconferencing and videoconferencing are maximally utilized to facilitate communication between the University of Texas Medical Branch, the lead institution for the CETR, and other participating institutions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI109711-01
Application #
8654246
Study Section
Special Emphasis Panel (ZAI1-LR-M (J1))
Project Start
Project End
Budget Start
2014-03-01
Budget End
2015-02-28
Support Year
1
Fiscal Year
2014
Total Cost
$155,501
Indirect Cost
$19,138
Name
University of Texas Medical Br Galveston
Department
Type
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555
Woolsey, Courtney; Geisbert, Joan B; Matassov, Demetrius et al. (2018) Postexposure Efficacy of Recombinant Vesicular Stomatitis Virus Vectors Against High and Low Doses of Marburg Virus Variant Angola in Nonhuman Primates. J Infect Dis 218:S582-S587
Gilchuk, Pavlo; Mire, Chad E; Geisbert, Joan B et al. (2018) Efficacy of Human Monoclonal Antibody Monotherapy Against Bundibugyo Virus Infection in Nonhuman Primates. J Infect Dis 218:S565-S573
Gilchuk, Pavlo; Kuzmina, Natalia; Ilinykh, Philipp A et al. (2018) Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein. Immunity 49:363-374.e10
Cross, Robert W; Mire, Chad E; Agans, Krystle N et al. (2018) Marburg and Ravn Viruses Fail to Cause Disease in the Domestic Ferret (Mustela putorius furo). J Infect Dis 218:S448-S452
Flyak, Andrew I; Kuzmina, Natalia; Murin, Charles D et al. (2018) Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2-MPER region. Nat Microbiol 3:670-677
Cross, Robert W; Mire, Chad E; Feldmann, Heinz et al. (2018) Post-exposure treatments for Ebola and Marburg virus infections. Nat Rev Drug Discov 17:413-434
Ilinykh, Philipp A; Santos, Rodrigo I; Gunn, Bronwyn M et al. (2018) Asymmetric antiviral effects of ebolavirus antibodies targeting glycoprotein stem and glycan cap. PLoS Pathog 14:e1007204
King, Liam B; Fusco, Marnie L; Flyak, Andrew I et al. (2018) The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding. Cell Host Microbe 23:101-109.e4
Mire, Chad E; Geisbert, Joan B; Borisevich, Viktoriya et al. (2017) Therapeutic treatment of Marburg and Ravn virus infection in nonhuman primates with a human monoclonal antibody. Sci Transl Med 9:
Mire, Chad E; Geisbert, Thomas W (2017) Neutralizing the Threat: Pan-Ebolavirus Antibodies Close the Loop. Trends Mol Med 23:669-671

Showing the most recent 10 out of 25 publications