The proposed Center for Excellence in Translational Research combines 4 related endeavors focused in the development of a rapid molecular diagnostic with which to diagnosed first and second line drug resistance to Mycobacteria tuberculosis. The administrative core of this center provide scientific leadership and support for the center through the PI and Scientific Advisory Board consulting closely with the research project Pis and collaborators. The core will provide administrative support to each ofthe 4 research projects and the Sequencing core including negotiation, execution, and monitoring of sub-contracts and consulting agreements, financial monitoring and invoice tracking, communications platforms and plans including project website and portal for dissemination and storage of key center documents, teleconference/videoconference/web-conference infrastructure, centralized scheduling of teleconferences and meetings and travel and meeting logistics . The core will also provide continuous monitoring and evaluation ofthe progress ofthe projects through tracking of milestones and will ensure project regulatory compliance for human subjects, animal protocols and BSL3 biosafety standards. Lastly, the core will work with the Scientific Advisory Committee to solicit and review Supplementary projects aligned to the goals of the Center.

Public Health Relevance

By supporting the activities of this Center, the Administrative Core will contribute to the development of a rapid diagnostic test that will enable early diagnosis and appropriate treatment of drug resistant TB.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-LR-M (J1))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Harvard University
United States
Zip Code
Farhat, Maha R; Jacobson, Karen R; Franke, Molly F et al. (2016) Gyrase Mutations Are Associated with Variable Levels of Fluoroquinolone Resistance in Mycobacterium tuberculosis. J Clin Microbiol 54:727-33
Farhat, Maha R; Sultana, Razvan; Iartchouk, Oleg et al. (2016) Genetic Determinants of Drug Resistance in Mycobacterium tuberculosis and Their Diagnostic Value. Am J Respir Crit Care Med 194:621-30
Rock, Jeremy M; Lang, Ulla F; Chase, Michael R et al. (2015) DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader. Nat Genet 47:677-81
Farhat, M R; Mitnick, C D; Franke, M F et al. (2015) Concordance of Mycobacterium tuberculosis fluoroquinolone resistance testing: implications for treatment. Int J Tuberc Lung Dis 19:339-41
Farhat, Maha R; Shapiro, B Jesse; Sheppard, Samuel K et al. (2014) A phylogeny-based sampling strategy and power calculator informs genome-wide associations study design for microbial pathogens. Genome Med 6:101