The Translational Core is designed to support CRDD projects by collecting and supplying well characterized specimens from humans, domestic animals and wildlife with infectious diseases, and providing access to CLIA laboratories at the New York State Department of Health Wadsworth Center (NYSDOHWC) and New York City Department of Health and Mental Hygiene (NYCDOHMH) that are staffed with public health personnel who have specific expertise in optimizing and validating diagnostic assays for clinical use. All CRDD projects?whether focused on direct detection of microbial genomic targets or of host transcripts or antibodies that provide indirect evidence of infection and of insights into host response?require specimens for discovery and diagnostic assay development and validation. Through membership in regional, national and global laboratory networks, Translational Core investigators Christina Egan (NYSDOHWC), William Karesh (EcoHealth Alliance), Lipkin (Cll) and Jay Varma (NYCDOHMH) enjoy unique access to a wide range of samples and isolates to support discovery and diagnostic aims. Application of new clinical assays requires validation using specific criteria and diverse specimen matrices. In New York State, assays must be validated by the NYSDOHWC. The validation application and approval process is comprehensive and comparable to and supportive of moving the assay through the FDA approval process. By engaging NYSDOHWC and NYCDOHMH from the outset, the Translational Core is poised to expedite translation of basic research in diagnostics into products that will be used in public health and clinical laboratories and enhance the prospects for commercialization.

Public Health Relevance

The Translational Core provides samples required for CRDD research projects as well as support for optimization and validation of diagnostic assays in the central clinical laboratories of the New York State Department of Health Wadsworth Center and the New York City Department of Health and Mental Hygiene. These functions will expedite the development and implementation of diagnostic tests that reduce the morbidity, mortality and economic costs of infectious diseases

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI109761-01
Application #
8655289
Study Section
Special Emphasis Panel (ZAI1-LR-M (J1))
Project Start
Project End
Budget Start
2014-03-07
Budget End
2015-02-28
Support Year
1
Fiscal Year
2014
Total Cost
$826,333
Indirect Cost
$158,637
Name
Columbia University
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Lindow, Janet C; Wunder Jr, Elsio A; Popper, Stephen J et al. (2016) Cathelicidin Insufficiency in Patients with Fatal Leptospirosis. PLoS Pathog 12:e1005943
Bouilly, Delphine; Hon, Jason; Daly, Nathan S et al. (2016) Single-Molecule Reaction Chemistry in Patterned Nanowells. Nano Lett 16:4679-85
Bacharach, Eran; Mishra, Nischay; Briese, Thomas et al. (2016) Characterization of a Novel Orthomyxo-like Virus Causing Mass Die-Offs of Tilapia. MBio 7:e00431-16
Beall, Anne; Yount, Boyd; Lin, Chun-Ming et al. (2016) Characterization of a Pathogenic Full-Length cDNA Clone and Transmission Model for Porcine Epidemic Diarrhea Virus Strain PC22A. MBio 7:e01451-15
Forero, Adriana; Tisoncik-Go, Jennifer; Watanabe, Tokiko et al. (2016) The 1918 Influenza Virus PB2 Protein Enhances Virulence through the Disruption of Inflammatory and Wnt-Mediated Signaling in Mice. J Virol 90:2240-53
Tisoncik-Go, Jennifer; Gasper, David J; Kyle, Jennifer E et al. (2016) Integrated Omics Analysis of Pathogenic Host Responses during Pandemic H1N1 Influenza Virus Infection: The Crucial Role of Lipid Metabolism. Cell Host Microbe 19:254-66
Warren, Steven B; Vernick, Sefi; Romano, Ethan et al. (2016) Complementary Metal-Oxide-Semiconductor Integrated Carbon Nanotube Arrays: Toward Wide-Bandwidth Single-Molecule Sensing Systems. Nano Lett 16:2674-9
Strouts, Fiona R; Popper, Stephen J; Partidos, Charalambos D et al. (2016) Early Transcriptional Signatures of the Immune Response to a Live Attenuated Tetravalent Dengue Vaccine Candidate in Non-human Primates. PLoS Negl Trop Dis 10:e0004731
Menachery, Vineet D; Yount Jr, Boyd L; Sims, Amy C et al. (2016) SARS-like WIV1-CoV poised for human emergence. Proc Natl Acad Sci U S A 113:3048-53
Tokarz, Rafal; Sameroff, Stephen; Hesse, Richard A et al. (2015) Discovery of a novel nidovirus in cattle with respiratory disease. J Gen Virol 96:2188-93

Showing the most recent 10 out of 32 publications