Abstract

The Administrative Core will be led by the PI, Peter Palese, with partial support by an experienced grants administrator, Nina Umerah, who will have space in the departmental office of the Department of Microbiology at the Icahn School of Medicine at Mount Sinai School. The Core will facilitate communication among the participants of the U19 and the NIAID and will be responsible for obtaining permits required by regulatory bodies both inside and outside of the institution. The Core will also be responsible for coordinating technology transfer issues arising from the work done with the support of the U19, organizing interactions between the Pis and the External Advisory Board, and maintaining a website and database. Ms. Umerah is highly skilled in grants management and IT and thus will be a great assistance in facilitating a smooth operation of this program.

Public Health Relevance

This program is aimed at a deeper understanding of molecular mechanisms that can be exploited to generate broadly protective interventions against influenza viruses. The administrative Core will be responsible for the day-to-day facilitation of the programmatic operations of the U19

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI109946-01
Application #
8667700
Study Section
Special Emphasis Panel (ZAI1-ZL-I (J1))
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
1
Fiscal Year
2014
Total Cost
$66,622
Indirect Cost
$11,448

  Institution

Name
Icahn School of Medicine at Mount Sinai
Department
Type
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Fulton, Benjamin O; Sun, Weina; Heaton, Nicholas S et al. (2018) The Influenza B Virus Hemagglutinin Head Domain Is Less Tolerant to Transposon Mutagenesis than That of the Influenza A Virus. J Virol 92:
Pardi, Norbert; Hogan, Michael J; Naradikian, Martin S et al. (2018) Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses. J Exp Med 215:1571-1588
Coughlan, Lynda; Palese, Peter (2018) Overcoming Barriers in the Path to a Universal Influenza Virus Vaccine. Cell Host Microbe 24:18-24
Krammer, Florian; Fouchier, Ron A M; Eichelberger, Maryna C et al. (2018) NAction! How Can Neuraminidase-Based Immunity Contribute to Better Influenza Virus Vaccines? MBio 9:
Chen, Yao-Qing; Wohlbold, Teddy John; Zheng, Nai-Ying et al. (2018) Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies. Cell 173:417-429.e10
Henry, Carole; Palm, Anna-Karin E; Krammer, Florian et al. (2018) From Original Antigenic Sin to the Universal Influenza Virus Vaccine. Trends Immunol 39:70-79
Broecker, Felix; Liu, Sean T H; Sun, Weina et al. (2018) Immunodominance of Antigenic Site B in the Hemagglutinin of the Current H3N2 Influenza Virus in Humans and Mice. J Virol 92:
Nachbagauer, Raffael; Shore, David; Yang, Hua et al. (2018) Broadly Reactive Human Monoclonal Antibodies Elicited following Pandemic H1N1 Influenza Virus Exposure Protect Mice against Highly Pathogenic H5N1 Challenge. J Virol 92:
Pardi, Norbert; Parkhouse, Kaela; Kirkpatrick, Ericka et al. (2018) Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies. Nat Commun 9:3361
Wang, Taia T; Bournazos, Stylianos; Ravetch, Jeffrey V (2018) Immunological responses to influenza vaccination: lessons for improving vaccine efficacy. Curr Opin Immunol 53:124-129

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