The Administrative Core will be led by the PI, Peter Palese, with partial support by an experienced grants administrator, Nina Umerah, who will have space in the departmental office of the Department of Microbiology at the Icahn School of Medicine at Mount Sinai School. The Core will facilitate communication among the participants of the U19 and the NIAID and will be responsible for obtaining permits required by regulatory bodies both inside and outside of the institution. The Core will also be responsible for coordinating technology transfer issues arising from the work done with the support of the U19, organizing interactions between the Pis and the External Advisory Board, and maintaining a website and database. Ms. Umerah is highly skilled in grants management and IT and thus will be a great assistance in facilitating a smooth operation of this program.

Public Health Relevance

This program is aimed at a deeper understanding of molecular mechanisms that can be exploited to generate broadly protective interventions against influenza viruses. The administrative Core will be responsible for the day-to-day facilitation of the programmatic operations of the U19

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI109946-01
Application #
8667700
Study Section
Special Emphasis Panel (ZAI1-ZL-I (J1))
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
1
Fiscal Year
2014
Total Cost
$66,622
Indirect Cost
$11,448
Name
Icahn School of Medicine at Mount Sinai
Department
Type
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Ho, Irvin Y; Bunker, Jeffrey J; Erickson, Steven A et al. (2016) Refined protocol for generating monoclonal antibodies from single human and murine B cells. J Immunol Methods 438:67-70
Chen, Chi-Jene; Ermler, Megan E; Tan, Gene S et al. (2016) Influenza A Viruses Expressing Intra- or Intergroup Chimeric Hemagglutinins. J Virol 90:3789-93
Krammer, Florian (2016) Novel universal influenza virus vaccine approaches. Curr Opin Virol 17:95-103
Nachbagauer, Raffael; Choi, Angela; Izikson, Ruvim et al. (2016) Age Dependence and Isotype Specificity of Influenza Virus Hemagglutinin Stalk-Reactive Antibodies in Humans. MBio 7:e01996-15
Tan, Gene S; Leon, Paul E; Albrecht, Randy A et al. (2016) Broadly-Reactive Neutralizing and Non-neutralizing Antibodies Directed against the H7 Influenza Virus Hemagglutinin Reveal Divergent Mechanisms of Protection. PLoS Pathog 12:e1005578
He, Wenqian; Tan, Gene S; Mullarkey, Caitlin E et al. (2016) Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus. Proc Natl Acad Sci U S A 113:11931-11936
Neu, Karlynn E; Henry Dunand, Carole J; Wilson, Patrick C (2016) Heads, stalks and everything else: how can antibodies eradicate influenza as a human disease? Curr Opin Immunol 42:48-55
DiLillo, David J; Palese, Peter; Wilson, Patrick C et al. (2016) Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection. J Clin Invest 126:605-10
Henry Dunand, Carole J; Leon, Paul E; Huang, Min et al. (2016) Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection. Cell Host Microbe 19:800-13
Hamilton, Jennifer R; Sachs, David; Lim, Jean K et al. (2016) Club cells surviving influenza A virus infection induce temporary nonspecific antiviral immunity. Proc Natl Acad Sci U S A 113:3861-6

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