The overall goal of the Administrative Core is to integrate and oversee all UM-ACE activities. The Core will provide administrative oversight to facilitate the mission of the Center and ensure that the UM-ACE meets its objectives and collaborates effectively within the broader ACE Program, under the guidance of the ACE Steering Committee. The Administrative Core will provide coordination for the Center and the three projects within this ACE application, and will be charged with ensuring regulatory compliance and effective financial management of resources within the Center. This Core will also facilitate collaborative efforts within the UMACE and between the UM-ACE and other institutions with funded ACE awards. The core will organize regular meetings for the leadership of the Center. The core will also organize and facilitate meetings that will be attended by the entire research teams of the three projects within the Center. The goals of these meetings are to address research planning and data collection strategies, present research data, discuss existing and potential new collaborations and resource sharing, and data discuss management and financial planning. The goals of the Administrative Core will be accomplished with the following Specific Aims: 1. Provide oversight and evaluation of progress towards the Center's objectives, financial management, and regulatory compliance, and 2. Establish effective communication and facilitate collaborations within the UM-ACE and with the collaborating ACE Institutions.

Public Health Relevance

The University of Michigan ACE Administrative Core will coordinate the Center activities, and manage collaborations with the other Autoimmunity Centers of Excellence to enhance early translation of promising interventions with supporting mechanistic studies to improve our understanding of autoimmune diseases.

Agency
National Institute of Health (NIH)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI110502-01
Application #
8732931
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Figueroa-Romero, Claudia; Hur, Junguk; Lunn, J Simon et al. (2016) Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms. Mol Cell Neurosci 71:34-45
Namas, Rajaie; Renauer, Paul; Ognenovski, Mikhail et al. (2016) Histone H2AX phosphorylation as a measure of DNA double-strand breaks and a marker of environmental stress and disease activity in lupus. Lupus Sci Med 3:e000148
Tsou, Pei-Suen; Wren, Jonathan D; Amin, M Asif et al. (2016) Histone Deacetylase 5 Is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repression of Proangiogenic Factors. Arthritis Rheumatol 68:2975-2985
Delaney, Colin; Garg, Sanjay K; Yung, Raymond (2015) Analysis of DNA Methylation by Pyrosequencing. Methods Mol Biol 1343:249-64