Malaria and HIV/AIDS are two of the most devastating infectious diseases, impacting millions of people world- wide. Effective vaccines against the pathogens that cause these diseases (HIV and Plasmodium falciparum) have proven elusive and traditional vaccine approaches are unlikely to succeed in eradicating either disease. In addition to our limited understanding of the desired immune responses to confer protection against the pathogens and our limited ability to elicit such responses, vaccine efficacy is also confounded by the diversity of pathogens, human populations, environmental exposures, and health status. The projects described herein are designed to support the identification of immune profiles that correlate with vaccine efficacy and are of potential relevance to protection against HIV-1 and P. falciparum infection. Beyond the importance of combatting these diseases, the strategies for profiling immunity in response to infection and vaccination hold promise for garnering fundamental insights into the complexity of the immune system as a whole. Such insight will have potential for impacting strategies for vaccine development and for treating immune-related diseases more broadly.

Public Health Relevance

Malaria and HIV/AIDS impact millions of people world-wide. Understanding and eliciting the desired immune responses to confer protection against the pathogens causing these diseases is key to developing effective vaccines. Such understanding is also central to developing strategies for vaccine development and treating immune-related diseases more broadly.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI128914-04
Application #
9730217
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Boggiano, Cesar Augusto
Project Start
2017-07-19
Project End
2022-06-30
Budget Start
2019-07-01
Budget End
2020-06-30
Support Year
4
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Seattle Children's Hospital
Department
Type
DUNS #
048682157
City
Seattle
State
WA
Country
United States
Zip Code
98105