This core C provides services, developments and infrastructure to support: (1) treatment planning and delivery activities for MGH for patients enrolled on clinical trial protocols, including protocol treatments using IMRT, 3D CRT and SOBP and PBS treatment fields;(2) quality, dosimetry and technical validation of protocol design and delivery, including quantifying workflow efficiencies and analysis of workflow safety modes;(3) advancement of optimization technologies in support of PBS treatment planning in the presence of time-dependencies and physical uncertainties;(5) a framework for development and deployment of treatment planning and verification resources in support of the above aims;and (5) Cloud-based access for other POI participating centers to deployed resources. This core supports the mission of the NCI to improve the treatment and continuing care of cancer patients.

Public Health Relevance

This research aims to improve radiation treatment for cancer patients by improving our ability to direct the radiation at the tumor to spare adjacent normal tissue by using protons (charged particles) with intensity- modulated proton therapy. This can potentially improve cancer cure rates, reduce side effects, or both, depending on the clinical scenario. With an increasing number of proton centers in the United States and abroad, the research in this program project is increasingly important for public health.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZCA1-RPRB-C (J1))
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Massachusetts General Hospital
United States
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Taylor, Paige A; Kry, Stephen F; Followill, David S (2017) Pencil Beam Algorithms Are Unsuitable for Proton Dose Calculations in Lung. Int J Radiat Oncol Biol Phys 99:750-756
DeLaney, Thomas F; Chen, Yen-Lin; Baldini, Elizabeth H et al. (2017) Phase 1 trial of preoperative image guided intensity modulated proton radiation therapy with simultaneously integrated boost to the high risk margin for retroperitoneal sarcomas. Adv Radiat Oncol 2:85-93
Mohan, Radhe; Grosshans, David (2017) Proton therapy - Present and future. Adv Drug Deliv Rev 109:26-44
Hall, David C; Trofimov, Alexei V; Winey, Brian A et al. (2017) Predicting Patient-specific Dosimetric Benefits of Proton Therapy for Skull-base Tumors Using a Geometric Knowledge-based Method. Int J Radiat Oncol Biol Phys 97:1087-1094
Zaghian, Maryam; Cao, Wenhua; Liu, Wei et al. (2017) Comparison of linear and nonlinear programming approaches for ""worst case dose"" and ""minmax"" robust optimization of intensity-modulated proton therapy dose distributions. J Appl Clin Med Phys 18:15-25
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Mohan, Radhe; Das, Indra J; Ling, Clifton C (2017) Empowering Intensity Modulated Proton Therapy Through Physics and Technology: An Overview. Int J Radiat Oncol Biol Phys 99:304-316
Unkelbach, Jan; Papp, Dávid; Gaddy, Melissa R et al. (2017) Spatiotemporal fractionation schemes for liver stereotactic body radiotherapy. Radiother Oncol 125:357-364
Niedzielski, Joshua S; Yang, Jinzhong; Stingo, Francesco et al. (2017) A Novel Methodology using CT Imaging Biomarkers to Quantify Radiation Sensitivity in the Esophagus with Application to Clinical Trials. Sci Rep 7:6034
Giantsoudi, Drosoula; Adams, Judith; MacDonald, Shannon M et al. (2017) Proton Treatment Techniques for Posterior Fossa Tumors: Consequences for Linear Energy Transfer and Dose-Volume Parameters for the Brainstem and Organs at Risk. Int J Radiat Oncol Biol Phys 97:401-410

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