The administrative Core A is responsible for providing all of the administrative support for the PPG. These responsibilities, carried out by the Administrative Coordinator (Ms. Eleni Yokas) under the supervision of the PI (M. F. Goodman), will consist of recruitment of staff and students for the individual projects and other two cores, arrange a calendar of PPG internal and external seminars, arrange transportation, lodging and meeting facilities for the project leaders, key investigators, and consortium collaborators for the PPG retreats at NIEHS and USC. Core A will interface with the Molecular and Computational Biology Section and the Chemistry Department at USC to schedule outside speakers as part of the two separate and well-established ongoing seminar series. Core A will also be responsible for scheduling special seminars. Core A will operate at USC.

National Institute of Health (NIH)
Research Program--Cooperative Agreements (U19)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Southern California
Los Angeles
United States
Zip Code
Kirby, Thomas W; Derose, Eugene F; Beard, William A et al. (2014) Substrate rescue of DNA polymerase ? containing a catastrophic L22P mutation. Biochemistry 53:2413-22
Wu, Sangwook; Beard, William A; Pedersen, Lee G et al. (2014) Structural comparison of DNA polymerase architecture suggests a nucleotide gateway to the polymerase active site. Chem Rev 114:2759-74
Prasad, Rajendra; Horton, Julie K; Chastain 2nd, Paul D et al. (2014) Suicidal cross-linking of PARP-1 to AP site intermediates in cells undergoing base excision repair. Nucleic Acids Res 42:6337-51
Freudenthal, Bret D; Beard, William A; Wilson, Samuel H (2014) Watching a DNA polymerase in action. Cell Cycle 13:691-2
Towle-Weicksel, Jamie B; Dalal, Shibani; Sohl, Christal D et al. (2014) Fluorescence resonance energy transfer studies of DNA polymerase ?: the critical role of fingers domain movements and a novel non-covalent step during nucleotide selection. J Biol Chem 289:16541-50
Beard, William A; Wilson, Samuel H (2014) Structure and mechanism of DNA polymerase ?. Biochemistry 53:2768-80
Oertell, Keriann; Chamberlain, Brian T; Wu, Yue et al. (2014) Transition state in DNA polymerase ? catalysis: rate-limiting chemistry altered by base-pair configuration. Biochemistry 53:1842-8
Hwang, Candy S; Kashemirov, Boris A; McKenna, Charles E (2014) On the observation of discrete fluorine NMR spectra for uridine 5'-?,?-fluoromethylenetriphosphate diastereomers at basic pH. J Org Chem 79:5315-9
Seamon, Kyle J; Hansen, Erik C; Kadina, Anastasia P et al. (2014) Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization. J Am Chem Soc 136:9822-5
Sassa, Akira; Ça?layan, Melike; Dyrkheeva, Nadezhda S et al. (2014) Base excision repair of tandem modifications in a methylated CpG dinucleotide. J Biol Chem 289:13996-4008