The CIFASD Informatics Core provides a research data resource to be used by investigators to explore the relationships of face, brain, and behavior to improve the diagnosis of FAS and work towards therapies for alcohol exposed children. The Informatics Core has the following specific aims for the next five years:
Aim 1 : Continued cyber infrastructure support. The Informatics Core will consult and collaborate with CIFASD clinical projects, cores, and developmental projects to support the existing data submission to the CIFASD Central Repository, manage those data, and make those data available for use to accomplish CIFASD goals.
Aim 2 : Collection of additional data sets. The Informatics Core will securely bring new data sets into the CIFASD Central Repository for cross-study and cross-modality data analysis amongst CIFASD projects.
Aim 3 : Support of affiliated projects. The Informatics Core will develop technical solutions that will allow the comparison of data between CIFASD and affiliated projects. The Informatics core will use the following methods to support the goals of this project and CIFASD: The ongoing management of standardized data in the CIFASD Central Repository will provide core consortium resources including;data input and bulk upload tools, a data dictionary to standardize terms across studies, a cross query tool so that data from multiple studies can be integrated for synthetic studies, and data browsing tools that enable investigators to ensure data quality. Expert consultation will support the input, export, and integration of data in the Central Repository to lower the barrier of use for investigators and improve data quality of synthetic studies. This consultation will also regularly report on data in the Central Repository to track consortium progress goals. Expert software engineering will provide new input tools and modify existing tools to support the changing needs of CIFASD projects as well as new research projects that are added as part of the third Phase of the CIFASD program.

Public Health Relevance

The goal of the CIFASD Informatics Core is to support research on the relationships efface, brain, and behavior in order to improve the diagnosis of Fetal Alcohol Spectrum Disorders and work towards therapies for alcohol exposed children. By providing a central, standardized data resource for CIFASD, the Informatics Core will provide a means by which comprehensive diagnostics and therapies can be developed.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Resource-Related Research Projects--Cooperative Agreements (U24)
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Special Emphasis Panel (ZAA1-CC (02))
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Dunty, Jr, William
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Indiana University Bloomington
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United States
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Wozniak, Jeffrey R; Mueller, Bryon A; Mattson, Sarah N et al. (2016) Functional connectivity abnormalities and associated cognitive deficits in fetal alcohol Spectrum disorders (FASD). Brain Imaging Behav :
Glass, Leila; Graham, Diana M; Deweese, Benjamin N et al. (2014) Correspondence of parent report and laboratory measures of inattention and hyperactivity in children with heavy prenatal alcohol exposure. Neurotoxicol Teratol 42:43-50
Ware, Ashley L; Glass, Leila; Crocker, Nicole et al. (2014) Effects of prenatal alcohol exposure and attention-deficit/hyperactivity disorder on adaptive functioning. Alcohol Clin Exp Res 38:1439-47
Nguyen, Tanya T; Glass, Leila; Coles, Claire D et al. (2014) The clinical utility and specificity of parent report of executive function among children with prenatal alcohol exposure. J Int Neuropsychol Soc 20:704-16
Ware, Ashley L; O'Brien, Jessica W; Crocker, Nicole et al. (2013) The effects of prenatal alcohol exposure and attention-deficit/hyperactivity disorder on psychopathology and behavior. Alcohol Clin Exp Res 37:507-16
Glass, Leila; Ware, Ashley L; Crocker, Nicole et al. (2013) Neuropsychological deficits associated with heavy prenatal alcohol exposure are not exacerbated by ADHD. Neuropsychology 27:713-24
Graham, Diana M; Crocker, Nicole; Deweese, Benjamin N et al. (2013) Prenatal alcohol exposure, attention-deficit/hyperactivity disorder, and sluggish cognitive tempo. Alcohol Clin Exp Res 37 Suppl 1:E338-46
Mattson, Sarah N; Roesch, Scott C; Glass, Leila et al. (2013) Further development of a neurobehavioral profile of fetal alcohol spectrum disorders. Alcohol Clin Exp Res 37:517-28
Ware, Ashley L; Crocker, Nicole; O'Brien, Jessica W et al. (2012) Executive function predicts adaptive behavior in children with histories of heavy prenatal alcohol exposure and attention-deficit/hyperactivity disorder. Alcohol Clin Exp Res 36:1431-41
Mattson, Sarah N; Foroud, Tatiana; Sowell, Elizabeth R et al. (2010) Collaborative initiative on fetal alcohol spectrum disorders: methodology of clinical projects. Alcohol 44:635-41

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