The Center for International Blood and Marrow Transplant Research (CIBMTR) is a clinical research program dedicated to addressing important issues in the field of hematopoietic cell transplantation (HCT). CIBMTR maintains a large outcomes registry with information for more than 330,000 HCT recipients in over 300 centers and provides statistical support for analyzing those data. A separately funded Research Repository of donor-recipient specimens linked to these clinical data is available for a large subset of patients. Use of this Resource by hundreds of investigators around the world during the current and previous funding cycles have contributed to >700 publications on important issues and to improved global collaboration in data exchange and HCT research. With continuation of U24-CA76518, CIBMTR will continue to build on the infrastructure made possible by this support to facilitate in-depth exploration of clinical, immunogenetic, quality of life, and health services issues related to HCT. This application proposes to enhance this Resource and to advance its utility through the following Specific Aims: Resource Development: Provide the biomedical community a high-quality clinical database and state-of-the-art statistical support to address important issues in HCT and related fields through continued enhancement of data collection and management technology and procedures, expansion of the Resource to include patient-reported outcomes, gathering and disseminating data necessary for health services research and data on some non-HCT patients, development and application of novel statistical techniques, and collaboration with national and international networks in HCT and related fields. Resource Utilization: Increase use of data and statistical resources maintained by the CIBMTR to support studies with important clinical and policy implications, and enhance Working and Advisory Committee and Statistical Center processes to prioritize and complete these studies.

Public Health Relevance

The CIBMTR continues to play a unique and important role in facilitating clinical research in HCT. It is committed to developing its research database and statistical capabilities to meet the needs of investigators in a rapidly evolving field. It will buld on the infrastructure made possible by support from U24-CA76518 and its partnerships to better serve the research and medical community and address important issues in HCT.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Resource-Related Research Projects--Cooperative Agreements (U24)
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Special Emphasis Panel (ZCA1-SRLB-V (J1))
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Merritt, William D
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Medical College of Wisconsin
Internal Medicine/Medicine
Schools of Medicine
United States
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Boyiadzis, Michael; Arora, Mukta; Klein, John P et al. (2015) Impact of Chronic Graft-versus-Host Disease on Late Relapse and Survival on 7,489 Patients after Myeloablative Allogeneic Hematopoietic Cell Transplantation for Leukemia. Clin Cancer Res 21:2020-8
Vij, Ravi; Kumar, Shaji; Zhang, Mei-Jie et al. (2015) Impact of pretransplant therapy and depth of disease response before autologous transplantation for multiple myeloma. Biol Blood Marrow Transplant 21:335-41
Hong, S; Le-Rademacher, J; Artz, A et al. (2015) Comparison of non-myeloablative conditioning regimens for lymphoproliferative disorders. Bone Marrow Transplant 50:367-74
Kornblit, Brian; Enevold, Christian; Wang, Tao et al. (2015) Toll-like receptor polymorphisms in allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 21:259-65
Bachanova, V; Burns, L J; Wang, T et al. (2015) Alternative donors extend transplantation for patients with lymphoma who lack an HLA matched donor. Bone Marrow Transplant 50:197-203
Copelan, Edward A; Avalos, Belinda R; Ahn, Kwang Woo et al. (2015) Comparison of outcomes of allogeneic transplantation for chronic myeloid leukemia with cyclophosphamide in combination with intravenous busulfan, oral busulfan, or total body irradiation. Biol Blood Marrow Transplant 21:552-8
Kim, Sung-Yong; Le Rademacher, Jennifer; Antin, Joseph H et al. (2014) Myelodysplastic syndrome evolving from aplastic anemia treated with immunosuppressive therapy: efficacy of hematopoietic stem cell transplantation. Haematologica 99:1868-75
Broux, B; Shamim, Z; Wang, T et al. (2014) The influence of interleukin-7 receptor ?-chain haplotypes on outcome after allogeneic hematopoietic cell transplantation. Int J Immunogenet 41:521-7
Eckrich, Michael J; Ahn, Kwang-Woo; Champlin, Richard E et al. (2014) Effect of race on outcomes after allogeneic hematopoietic cell transplantation for severe aplastic anemia. Am J Hematol 89:125-9
Kelly, Michael J; Horan, John T; Alonzo, Todd A et al. (2014) Comparable survival for pediatric acute myeloid leukemia with poor-risk cytogenetics following chemotherapy, matched related donor, or unrelated donor transplantation. Pediatr Blood Cancer 61:269-75

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