Advanced Technology QA Center Our plan is to capitalize on the infrastructure and strengths of the nation's existing quality assurance (QA) programs that comprise our Advanced Technology QA Consortium (ATC), including the Image-Guided Therapy Center (ITC), Radiation Therapy Oncology Group (RTOG), Radiological Physics Center (RPC), and the Quality Assurance Review Center (QARC) to maintain/develop an advanced medical informatics infrastructure that provides an environment in which institutions can submit, and QA Centers can receive, share, and analyze volumetric multimodality imaging/treatment planning/verification (ITPV) digital data. Specifically, we will (1) maintain/manage (and make incremental improvements as required to) the current electronic data submission of advanced technology (3DCRT, IMRT, SBRT, and brachytherapy) protocol credentialing and case data, archival storage, and remote QA review process utilizing ATC Method-1 (now referred to as the QuASAR-1 (Quality Assurance Submission, Analysis, and Review-1) system);(2) develop novel web-based remote-review tools that will enhance the efficient and effective review of protocols utilizing advanced technologies. The design infrastructure of these tools will assist the development of future protocol processes such as image-guided radiation therapy (IGRT) and adaptive radiation therapy (ART). The proposed system is referred to as QuASAR-2 and will be modular in design to promote efficient tools and subsystems development that achieve compatibility with existing software standards, including the Cancer Bioinformatics Grid (caBIG) and DICOM RT, and maintain/develop archival ITPV, credentialing/QA databases that can be linked with the cooperative group's clinical outcomes database;(3) assist cooperative groups in the development and management of advanced technology clinical trials protocols including (a) tumor/target volume and organ at risk definitions;(b) credentialing requirements and evaluation criteria;(c) electronic data submission requirements/instructions;(d) QA review procedures;and (4) serve as an educational resource to the nation's clinical trial cooperative groups and participating institutions for support of advanced technology radiation therapy clinical trials. Our ATC QA consortium approach will help avoid duplication of service/developmental efforts and promote development of uniform credentialing/QA criteria for clinical trials throughout all Cooperative Groups.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
3U24CA081647-13S2
Application #
8690240
Study Section
Special Emphasis Panel (ZCA1-SRRB-9 (M2))
Program Officer
Deye, James
Project Start
1999-07-22
Project End
2014-02-28
Budget Start
2013-07-01
Budget End
2014-02-28
Support Year
13
Fiscal Year
2013
Total Cost
$1,287,846
Indirect Cost
$273,886
Name
Washington University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
McKenzie, Elizabeth M; Balter, Peter A; Stingo, Francesco C et al. (2014) Reproducibility in patient-specific IMRT QA. J Appl Clin Med Phys 15:4741
Viswanathan, Akila N; Erickson, Beth; Gaffney, David K et al. (2014) Comparison and consensus guidelines for delineation of clinical target volume for CT- and MR-based brachytherapy in locally advanced cervical cancer. Int J Radiat Oncol Biol Phys 90:320-8
Cho, Jongmin; Summers, Paige A; Ibbott, Geoffrey S (2014) An anthropomorphic spine phantom for proton beam approval in NCI-funded trials. J Appl Clin Med Phys 15:4742
Hsu, I-Chow; Hunt, Daniel; Straube, William et al. (2014) Dosimetric analysis of radiation therapy oncology group 0321: the importance of urethral dose. Pract Radiat Oncol 4:27-34
Hong, Theodore S; Bosch, Walter R; Krishnan, Sunil et al. (2014) Interobserver variability in target definition for hepatocellular carcinoma with and without portal vein thrombus: radiation therapy oncology group consensus guidelines. Int J Radiat Oncol Biol Phys 89:804-13
Schefter, Tracey; Winter, Kathryn; Kwon, Janice S et al. (2014) RTOG 0417: efficacy of bevacizumab in combination with definitive radiation therapy and cisplatin chemotherapy in untreated patients with locally advanced cervical carcinoma. Int J Radiat Oncol Biol Phys 88:101-5
Grant, Ryan L; Summers, Paige A; Neihart, James L et al. (2014) Relative stopping power measurements to aid in the design of anthropomorphic phantoms for proton radiotherapy. J Appl Clin Med Phys 15:4523
Jabbour, Salma K; Hashem, Sameh A; Bosch, Walter et al. (2014) Upper abdominal normal organ contouring guidelines and atlas: a Radiation Therapy Oncology Group consensus. Pract Radiat Oncol 4:82-9
Faught, Austin M; Kry, Stephen F; Luo, Dershan et al. (2013) Development of a modified head and neck quality assurance phantom for use in stereotactic radiosurgery trials. J Appl Clin Med Phys 14:4313
Kry, Stephen F; Alvarez, Paola; Molineu, Andrea et al. (2013) Algorithms used in heterogeneous dose calculations show systematic differences as measured with the Radiological Physics Center's anthropomorphic thorax phantom used for RTOG credentialing. Int J Radiat Oncol Biol Phys 85:e95-100

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