The primary objective of the imaging and Radiation Oncology Core (IROC) Group is to provide scientific and technical expertise for incorporation of appropriate, integrated Quality Assurance (QA) and image data management for both imaging and radiotherapy (RT) in applicable trials conducted by the National Clinical Trials Network (NCTN) Program. The leading QA centers;RPC, QARC, RTOG QA, ITC, ACRIN and CALGB/SWOG Imaging Core lab, in the current NCI Cooperative Group Program have joined together to form the IROC Group, administratively organized through the American College of Radiology (ACR) Clinical Research Center. The creation of IROC capitalizes on existing infrastructure and expertise at QA Centers currently providing services to the NCI Cooperative Groups. Work flows, processes and information systems currently in place will be further enhanced taking the best practices and standards in an integrated vision. The interdependencies between imaging and RT will be synergized in this QA Group eliminating duplication of services and optimizing towards efficient and effective workflows. A major strength of IROC will be the development of consistent standard operating procedures for all imaging and RT aspects of the NCTN and to facilitate a seamless flow of imaging and RT patient case datasets across the network. IROC's organizational structure allows the delivery of a broad array of imaging and RT QA services including Site Qualification;Trial Design Support;Credentialing;Data Management (Pre- and Post- Review);and Case Review. An information technology infrastructure will be developed that harmonizes IROC services, data collection, assessment and management for the NCTN Groups'clinical trials. IROC will implement programs that assure consistent high quality imaging and RT planning/delivery across the NCTN participating sites. IROC members will collaborate with the NCTN disease/modality committees within each Network Group to provide an optimal and effective imaging and RT core service. IROC will analyze QA data obtained prospectively/retrospectively to further advance QA science. IROC will manage all aspects of QA for NCTN trials that includes imaging and/or RT with the shared goal to achieve the best possible trial outcomes.

Public Health Relevance

Today's cancer trials frequently require the use of imaging and/or RT to achieve the most effective treatment. Rigorous QA of these methodologies secures consistency across the participating sites by managing potential variability which would otherwise obscure true therapeutic outcomes.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-GRB-I (O1))
Program Officer
Mooney, Margaret M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
American College of Radiology
United States
Zip Code
Cui, Yunfeng; Chen, Wenzhou; Kong, Feng-Ming Spring et al. (2015) Contouring variations and the role of atlas in non-small cell lung cancer radiation therapy: Analysis of a multi-institutional preclinical trial planning study. Pract Radiat Oncol 5:e67-75
Grant, Ryan L; Summers, Paige A; Neihart, James L et al. (2014) Relative stopping power measurements to aid in the design of anthropomorphic phantoms for proton radiotherapy. J Appl Clin Med Phys 15:4523
Jabbour, Salma K; Hashem, Sameh A; Bosch, Walter et al. (2014) Upper abdominal normal organ contouring guidelines and atlas: a Radiation Therapy Oncology Group consensus. Pract Radiat Oncol 4:82-9
Pulliam, Kiley B; Followill, David; Court, Laurence et al. (2014) A six-year review of more than 13,000 patient-specific IMRT QA results from 13 different treatment sites. J Appl Clin Med Phys 15:4935
Melidis, Christos; Bosch, Walter R; Izewska, Joanna et al. (2014) Radiation therapy quality assurance in clinical trials--Global Harmonisation Group. Radiother Oncol 111:327-9
McKenzie, Elizabeth M; Balter, Peter A; Stingo, Francesco C et al. (2014) Reproducibility in patient-specific IMRT QA. J Appl Clin Med Phys 15:4741
Kry, Stephen F; Molineu, Andrea; Kerns, James R et al. (2014) Institutional patient-specific IMRT QA does not predict unacceptable plan delivery. Int J Radiat Oncol Biol Phys 90:1195-201
Pulliam, Kiley B; Huang, Jessie Y; Howell, Rebecca M et al. (2014) Comparison of 2D and 3D gamma analyses. Med Phys 41:021710
McEwen, Malcolm; DeWerd, Larry; Ibbott, Geoffrey et al. (2014) Addendum to the AAPM's TG-51 protocol for clinical reference dosimetry of high-energy photon beams. Med Phys 41:041501
Gibbons, John P; Antolak, John A; Followill, David S et al. (2014) Monitor unit calculations for external photon and electron beams: Report of the AAPM Therapy Physics Committee Task Group No. 71. Med Phys 41:031501

Showing the most recent 10 out of 20 publications