The Administrative Core provides centralized offices for the coordination of the Yale Mouse Metabolic Phenotypic Center (MMPC) research activities. The Administrative Core operates under the supervision of the Program Director and the Associate Program Director. The principle functions of the Administrative Core are as follows: ?Administrative and Financial Management ?Prioritization of Scientific Core usage by Users ?Coordination for Importing Mice from Extramural Institutions ?Material Transfer Agreements ?Cost sharing for use of the Scientific Cores ?Data Exchange and Confidentiality ?Feedback and Quality Control ?Administration ofthe Pilot and Feasibility Project Program ?Provision of a Scientific Enrichment Program ?Maintenance ofthe Yale MMPC Web Page ?Maintenance ofthe Yale MMPC Data Base ?Education and Training ? Research and Development In consultation with the MMPC/ AMDCC Coordinating and Bioinformatics Unit, the Administrative Core also maintains Center budgetary and workflow records;oversees the importation and workflow assignments for strains submitted for services;establishes, standardizes, documents and distributes phenotyping protocols; and provides for quality control and budgetary oversight. Whereas the significance and quality of the Yale MMPC is defined by its phenotyping cores, the Administrative Core promotes efficient operation of the Center and ensures its vitality and success.

Public Health Relevance

The Administrative Core provides centralized offices for the coordination of the Yale Mouse Metabolic Phenotypic Center (MMPC) research activities. It is anticipated that the results obtained from characterizing these mice at the Yale MMPC will provide important new insights into the pathogenesis and complications relating to diabetes and obesity in humans.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24DK059635-09
Application #
8708027
Study Section
Special Emphasis Panel (ZDK1-GRB-S)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
9
Fiscal Year
2014
Total Cost
$21,458
Indirect Cost
$8,570
Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Qiu, Yang; Perry, Rachel J; Camporez, João-Paulo G et al. (2018) In vivo studies on the mechanism of methylene cyclopropyl acetic acid and methylene cyclopropyl glycine-induced hypoglycemia. Biochem J 475:1063-1074
Budatha, Madhusudhan; Zhang, Jiasheng; Zhuang, Zhen W et al. (2018) Inhibiting Integrin ?5 Cytoplasmic Domain Signaling Reduces Atherosclerosis and Promotes Arteriogenesis. J Am Heart Assoc 7:
Jelenik, Tomas; Flögel, Ulrich; Álvarez-Hernández, Elisa et al. (2018) Insulin Resistance and Vulnerability to Cardiac Ischemia. Diabetes 67:2695-2702
Corbit, Kevin C; Camporez, João Paulo G; Edmunds, Lia R et al. (2018) Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling. Diabetes 67:208-221
Perry, Rachel J; Peng, Liang; Cline, Gary W et al. (2018) Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes. Cell Metab 27:210-217.e3
Majtan, Tomas; Jones Jr, Wendell; Krijt, Jakub et al. (2018) Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria. Mol Ther 26:834-844
Perry, Rachel J; Wang, Yongliang; Cline, Gary W et al. (2018) Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation. Cell 172:234-248.e17
Lawan, Ahmed; Min, Kisuk; Zhang, Lei et al. (2018) Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance. Diabetes 67:624-635
Vatner, Daniel F; Goedeke, Leigh; Camporez, Joao-Paulo G et al. (2018) Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents. Diabetologia 61:1435-1446
Wang, Yongliang; Nasiri, Ali R; Damsky, William E et al. (2018) Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer. Cell Rep 24:47-55

Showing the most recent 10 out of 255 publications