The long-range objectives of the UC Davis MMPC Complications and Pathology Core are to provide detailed metabolic phenotyping of mice for the complications of diabetes and obesity. We will focus our efforts on comprehensively phenotyping macrovascular and microvascular complications of diabetes and obesity. Diabetic and obesity phenotyping complications will be accomplished through the coordinated distribution and focused analyses of mice by the leader and co-leader of the core, Drs. Rutledge and Griffey, respectively. In addition, investigators using the core will gain access to the academic portal at UC Davis for comprehensive analysis of macrovascular and microvascular complications of diabetes and obesity. Investigators participating in this core and who have essential and special capabilities to phenotype macrovascular and microvascular complications are Drs. Rutledge, Griffey, Villablanca, Huser, Jin, Chiamvimovat, Ferrara, Nolta, and Van de Water.We have developed a comprehensive list of standard cardiovascular phenotyping assays. Review ofthe current list of national MMPC assays reveals needs in some areas. The UC Davis Complications and Pathology Core will fill some of these unmet needs using novel or new state-of-the-art approaches. These standard and new state-of-the-art and novel assays will be integrated with the other cores to better understand adipocyte biology, fatty liver disease, and insulin resistance.UC Davis has existing capabilities in mouse cardiovascular anatomy, physiology, pathology, and micro imaging that are outstanding. We will capitalize upon these assets to provide sophisticated cardiovascular phenotyping to users of the MMPC. Our mission is to ensure that efficient and accurate standard and novel and new state-of-the-art assays of submitted mice are provided to users ofthe UC Davis MMPC.
Mouse models of diabetes, diabetic complications, obesity and other related disorders have been invaluable for elucidating the disease potential, pathogenesis and treatment of these conditions in the human population. The Complications and Pathology Core will conduct procedures and analyses on mouse lines submitted to the MMPC-UCD in order to identify potentail mouse models of human disease for study.
|McGavigan, Anne K; Garibay, Darline; Henseler, Zachariah M et al. (2017) TGR5 contributes to glucoregulatory improvements after vertical sleeve gastrectomy in mice. Gut 66:226-234|
|Ito, Yoshihiro; Hsu, Ming-Fo; Bettaieb, Ahmed et al. (2017) Protein tyrosine phosphatase 1B deficiency in podocytes mitigates hyperglycemia-induced renal injury. Metabolism 76:56-69|
|Bettaieb, Ahmed; Koike, Shinichiro; Chahed, Samah et al. (2017) Podocyte-specific soluble epoxide hydrolase deficiency in mice attenuates acute kidney injury. FEBS J 284:1970-1986|
|Bettaieb, Ahmed; Koike, Shinichiro; Hsu, Ming-Fo et al. (2017) Soluble epoxide hydrolase in podocytes is a significant contributor to renal function under hyperglycemia. Biochim Biophys Acta 1861:2758-2765|
|Jung, Chris J; Zhang, Junli; Trenchard, Elizabeth et al. (2017) Efficient gene targeting in mouse zygotes mediated by CRISPR/Cas9-protein. Transgenic Res 26:263-277|
|Green, Adrian J; Graham, James L; Gonzalez, Eduardo A et al. (2017) Perinatal triphenyl phosphate exposure accelerates type 2 diabetes onset and increases adipose accumulation in UCD-type 2 diabetes mellitus rats. Reprod Toxicol 68:119-129|
|Vogel Ciernia, Annie; Pride, Michael C; Durbin-Johnson, Blythe et al. (2017) Early motor phenotype detection in a female mouse model of Rett syndrome is improved by cross-fostering. Hum Mol Genet 26:1839-1854|
|Roberts, Megan N; Wallace, Marita A; Tomilov, Alexey A et al. (2017) A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab 26:539-546.e5|
|Hsu, Ming-Fo; Bettaieb, Ahmed; Ito, Yoshihiro et al. (2017) Protein tyrosine phosphatase Shp2 deficiency in podocytes attenuates lipopolysaccharide-induced proteinuria. Sci Rep 7:461|
|Ng, Kit Fai; Anderson, Steve; Mayo, Patrice et al. (2016) Characterizing blood-brain barrier perturbations after exposure to human triglyceride-rich lipoprotein lipolysis products using MRI in a rat model. Magn Reson Med 76:1246-51|
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